EFFECT OF LOW DOSE ASA MEDICATION ON COAGULATION PARAMETERS IN RABBITS WITH RIGHT-VENTRICLE PACING

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F15%3A43874010" target="_blank" >RIV/62157124:16170/15:43874010 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF LOW DOSE ASA MEDICATION ON COAGULATION PARAMETERS IN RABBITS WITH RIGHT-VENTRICLE PACING

Popis výsledku v původním jazyce

Introduction. Antiaggregant therapy is standard in humans with permanent cardiac pacing due to presence of foreign material in right chamber and risk of thromboembolism. However, not all patients follow the instructions and not all patients tolerate ASA.The aim of this study was to evaluate safeness of pacing without ASA on animal model using rabbits. Material and methods. Eight clinically healthy New Zealand rabbit of age 14 weeks were used for this study. After placing of right-ventricle pacer, rabbits were receiving marbofloxacinum (2 mg/kg) and tolfenamic acid (0.1 ml/kg) for 7 days. From eighth day they were medicated with metoprolol (50 mg/l of water) and half of them with ASA (12.5 mg/l of water). Blood was collected 5., 9. and 11. week after ASA medication into citrate and EDTA test tubes. Activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT) fibrinogen (FBG), D-dimers (D-D) and platelet count were estimated. Results. Significant differences w

Název v anglickém jazyce

EFFECT OF LOW DOSE ASA MEDICATION ON COAGULATION PARAMETERS IN RABBITS WITH RIGHT-VENTRICLE PACING

Popis výsledku anglicky

Introduction. Antiaggregant therapy is standard in humans with permanent cardiac pacing due to presence of foreign material in right chamber and risk of thromboembolism. However, not all patients follow the instructions and not all patients tolerate ASA.The aim of this study was to evaluate safeness of pacing without ASA on animal model using rabbits. Material and methods. Eight clinically healthy New Zealand rabbit of age 14 weeks were used for this study. After placing of right-ventricle pacer, rabbits were receiving marbofloxacinum (2 mg/kg) and tolfenamic acid (0.1 ml/kg) for 7 days. From eighth day they were medicated with metoprolol (50 mg/l of water) and half of them with ASA (12.5 mg/l of water). Blood was collected 5., 9. and 11. week after ASA medication into citrate and EDTA test tubes. Activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time (TT) fibrinogen (FBG), D-dimers (D-D) and platelet count were estimated. Results. Significant differences w

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

<a href="/cs/project/NT14591" target="_blank" >NT14591: Plazmatické markry aktivace koagulace u pacientů se zavedenou endokardiální elektrodou</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů