Epidemiology of strongylid infections in humans and wild great apes from several locations across Central and East Africa

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F16%3A43874670" target="_blank" >RIV/62157124:16170/16:43874670 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16810/16:43874670

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Epidemiology of strongylid infections in humans and wild great apes from several locations across Central and East Africa

Popis výsledku v původním jazyce

The close phylogenetic relationship between great apes and humans can potentially result in pathogen exchange. The interface for transmission of infectious diseases has increased in recent years due to closer and more frequent contact between wild apes and people. We have been studying diversity and transmission of strongylid nematodes between wild endangered African great apes and humans co-inhabiting tropical forest habitats. Hundreds of fecal samples and L3 infectious larvae developed from human and ape coprocultures from several locations across Central and East Africa (Dzanga-Sangha Protected Areas, Central African Republic, Dja FR and Campo Ma'an NP, Cameroon and Issa Valley, Tanzania) were analyzed using state-of-the-art techniques in molecular epidemiology: next generation sequencing (NGS) with the Illumina Miseq platform. Current results on wild western lowland gorillas, chimpanzees and humans revealed a high diversity of strongylid nematodes, mainly from genera Necator and Oesophagostomum confirming transmission of Nector species between great apes and humans and leading to the discovery of a new nematode species affecting humans. The situation at each site reflects local ecological conditions and levels of ape-human contact. The transmission of infectious agents between humans and non-human primates poses a risk not only to endangered non-human primates, but also to humans. These results have high conservation value and have the potential to inform management decisions towards the control of threats to both great ape and human health.

Název v anglickém jazyce

Epidemiology of strongylid infections in humans and wild great apes from several locations across Central and East Africa

Popis výsledku anglicky

The close phylogenetic relationship between great apes and humans can potentially result in pathogen exchange. The interface for transmission of infectious diseases has increased in recent years due to closer and more frequent contact between wild apes and people. We have been studying diversity and transmission of strongylid nematodes between wild endangered African great apes and humans co-inhabiting tropical forest habitats. Hundreds of fecal samples and L3 infectious larvae developed from human and ape coprocultures from several locations across Central and East Africa (Dzanga-Sangha Protected Areas, Central African Republic, Dja FR and Campo Ma'an NP, Cameroon and Issa Valley, Tanzania) were analyzed using state-of-the-art techniques in molecular epidemiology: next generation sequencing (NGS) with the Illumina Miseq platform. Current results on wild western lowland gorillas, chimpanzees and humans revealed a high diversity of strongylid nematodes, mainly from genera Necator and Oesophagostomum confirming transmission of Nector species between great apes and humans and leading to the discovery of a new nematode species affecting humans. The situation at each site reflects local ecological conditions and levels of ape-human contact. The transmission of infectious agents between humans and non-human primates poses a risk not only to endangered non-human primates, but also to humans. These results have high conservation value and have the potential to inform management decisions towards the control of threats to both great ape and human health.

Druh

O - Ostatní výsledky

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů