Role of planar cell polarity pathway in ameloblastoma with focus on Frizzled 6

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F17%3A43875545" target="_blank" >RIV/62157124:16170/17:43875545 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Role of planar cell polarity pathway in ameloblastoma with focus on Frizzled 6

Popis výsledku v původním jazyce

Ameloblastoma is the most common epithelial odontogenic tumour in the oral cavity. Its progression is usually slow and the surface is covered by an oral mucosa with physiologic appearance. These tumors do not cause any pain to the patient and therefore it is difficult to diagnose them on time and the first signs are often missed by clinician leading to late diagnosis. The majority of ameloblastomas are benign in their biological behaviour, but they can be very locally invasive and recidivism after a surgery is very usual phenomena. Ameloblastoma grows into the surrounding tissues and they form very complex interlacing structures. However, what regulates this kind of aggressive behaviour reminds unknown. We focused on the expression pattern and possible role of Planar Cell Polarity Pathway (PCP) in pathogenesis of thise neoplasm. One of the very important molecules in this cell signalling pathway is receptor Frizzled 6 (FZD6), which we selected for further immunohistochemical analysis with the aim to evaluate its expression in tissues as well as on subcellular levels. Moreover, we used cytokeratin as a marker of epithelial cells, SOX2 as a marker of progenitor cells and PCNA to evaluate proliferating cell distribution. We also compared an expression pattern of these molecules in ameloblastoma with their distribution in a radicular and follicular cysts, which represent common pseudo tumorous lesions of odontogenic origin.

Název v anglickém jazyce

Role of planar cell polarity pathway in ameloblastoma with focus on Frizzled 6

Popis výsledku anglicky

Ameloblastoma is the most common epithelial odontogenic tumour in the oral cavity. Its progression is usually slow and the surface is covered by an oral mucosa with physiologic appearance. These tumors do not cause any pain to the patient and therefore it is difficult to diagnose them on time and the first signs are often missed by clinician leading to late diagnosis. The majority of ameloblastomas are benign in their biological behaviour, but they can be very locally invasive and recidivism after a surgery is very usual phenomena. Ameloblastoma grows into the surrounding tissues and they form very complex interlacing structures. However, what regulates this kind of aggressive behaviour reminds unknown. We focused on the expression pattern and possible role of Planar Cell Polarity Pathway (PCP) in pathogenesis of thise neoplasm. One of the very important molecules in this cell signalling pathway is receptor Frizzled 6 (FZD6), which we selected for further immunohistochemical analysis with the aim to evaluate its expression in tissues as well as on subcellular levels. Moreover, we used cytokeratin as a marker of epithelial cells, SOX2 as a marker of progenitor cells and PCNA to evaluate proliferating cell distribution. We also compared an expression pattern of these molecules in ameloblastoma with their distribution in a radicular and follicular cysts, which represent common pseudo tumorous lesions of odontogenic origin.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40300 - Veterinary science

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů