Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F17%3A43875575" target="_blank" >RIV/62157124:16170/17:43875575 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00095956 RIV/62157124:16370/17:43875575

Výsledek na webu

<a href="http://dx.doi.org/10.2174/1567201813666160502142856" target="_blank" >http://dx.doi.org/10.2174/1567201813666160502142856</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1567201813666160502142856" target="_blank" >10.2174/1567201813666160502142856</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Popis výsledku v původním jazyce

Background: Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions. Furthermore, there has been a noticeable increase in microorganisms resistant to these preparations. Mucoadhesive buccal films represent a modern therapeutic system for the treatment of oral mucosal fungal infection paired with a high degree of patient compliance. Ciclopirox olamine applied directly onto the oral mucosa offers an attractive alternative to treatment with systemic antifungals thanks to its low incidence of resistance and side effects. Objective: The aim of this work was to evaluate the pharmacokinetic parameters of ciclopirox olamine after the buccal application of mucoadhesive film prepared by the solvent casting method. Method: A chromatographic method using an internal standard was developed and validated for evaluation of ciclopirox olamine plasma concentrations. Method accuracy was 88.5-104.6% and 89.5-99.7% for interday and intraday assays, respectively. Results: The pharmacokinetic properties of ciclopirox olamine were studied in New Zealand White rabbits. The mucoadhesive films containing ciclopirox olamine in a total dose of 34.4 (33.0; 35.9) mg/kg were applied to all the rabbits. Plasma ciclopirox olamine concentrations were determined during the 12 h following application. The time taken to reach maximum plasma concentration was 1.7 (1.1; 2.2) h after the drug administration with cmax 5.73 (4.18; 7.28) ?g/ml. Overall elimination half-life was 3.8 (1.9; 10.8) h. Conclusion: The experiment suggests that oral mucoadhesive film may be a valuable alternative ciclopirox olamine administration.

Název v anglickém jazyce

Pharmacokinetics of Ciclopirox Olamine after Buccal Administration in Rabbits

Popis výsledku anglicky

Background: Prevalence of oral mucosal fungal infections increases with the frequent administration of antibiotics, corticosteroids and immunosuppressive drugs. Therapeutically used antifungals are usually associated with a variety of drug interactions. Furthermore, there has been a noticeable increase in microorganisms resistant to these preparations. Mucoadhesive buccal films represent a modern therapeutic system for the treatment of oral mucosal fungal infection paired with a high degree of patient compliance. Ciclopirox olamine applied directly onto the oral mucosa offers an attractive alternative to treatment with systemic antifungals thanks to its low incidence of resistance and side effects. Objective: The aim of this work was to evaluate the pharmacokinetic parameters of ciclopirox olamine after the buccal application of mucoadhesive film prepared by the solvent casting method. Method: A chromatographic method using an internal standard was developed and validated for evaluation of ciclopirox olamine plasma concentrations. Method accuracy was 88.5-104.6% and 89.5-99.7% for interday and intraday assays, respectively. Results: The pharmacokinetic properties of ciclopirox olamine were studied in New Zealand White rabbits. The mucoadhesive films containing ciclopirox olamine in a total dose of 34.4 (33.0; 35.9) mg/kg were applied to all the rabbits. Plasma ciclopirox olamine concentrations were determined during the 12 h following application. The time taken to reach maximum plasma concentration was 1.7 (1.1; 2.2) h after the drug administration with cmax 5.73 (4.18; 7.28) ?g/ml. Overall elimination half-life was 3.8 (1.9; 10.8) h. Conclusion: The experiment suggests that oral mucoadhesive film may be a valuable alternative ciclopirox olamine administration.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/NT14477" target="_blank" >NT14477: Moderní léková forma pro terapii orálních kandidóz</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Drug Delivery

ISSN

1567-2018

e-ISSN

—

Svazek periodika

14

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

AE - Spojené arabské emiráty

Počet stran výsledku

10

Strana od-do

99-108

Kód UT WoS článku

000399783000011

EID výsledku v databázi Scopus

—