Influence of butorphanol or fentanyl on intraocular pressure in dogs: a preliminary clinical study

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of butorphanol or fentanyl on intraocular pressure in dogs: a preliminary clinical study

Popis výsledku v původním jazyce

Purpose: The aim of this study was to assess the effects of two different analgesics on intraocular pressure in dogs. Methods: This was a prospective, randomized, double &quot;blinded&quot; clinical study. Twenty client-owned healthy dogs, body weight 12.9 ? 11.3 kg (mean ? SD) and age 8.3 ? 2.8 years, 10 males and 10 females of different breeds with no ocular abnormalities scheduled for periodontal treatment were randomly allocated into two groups receiving either butorphanol 0.2 mg/kg intravenously (group BUT) or fentanyl 0.01 mg/kg intravenously (group FEN). Intraocular pressure (IOP; TonoPen XL), pupil size (PUP; pupil gauge), heart rate (HR), respiratory frequency (fR) and systolic and diastolic arterial blood pressures (SAP, DAP; Cardel 9401, Midmark) were measured prior to (baseline) and at 5 and 10 minutes after drug administration (T5, T10). Data were analyzed by Shapiro Wilk, ANOVA and Mann-Whitney tests. Results: In the FEN group a significant increase of IOP was observed at T5 (P = 0,0328) and T10 (P = 0,0488). A significant decrease of PUP at T5 and T10 was detected in both, the BUT and FEN groups (P &lt; 0.05). In the FEN group HR dropped significantly at T10 (P = 0,0388), fR increased at T5 (P = 0,0340). In the BUT group SAP decreased at T5 and DAP at T5 and T10 (P &lt; 0.05). Conclusions: Within 10 minutes after administration fentanyl significantly increased intraocular pressure and decreased pupil size, butorphanol significantly decreased pupil size only. Support: Institutional founds of UVPS Brno and IGA 109/2017/FVL.

Název v anglickém jazyce

Influence of butorphanol or fentanyl on intraocular pressure in dogs: a preliminary clinical study

Popis výsledku anglicky

Purpose: The aim of this study was to assess the effects of two different analgesics on intraocular pressure in dogs. Methods: This was a prospective, randomized, double &quot;blinded&quot; clinical study. Twenty client-owned healthy dogs, body weight 12.9 ? 11.3 kg (mean ? SD) and age 8.3 ? 2.8 years, 10 males and 10 females of different breeds with no ocular abnormalities scheduled for periodontal treatment were randomly allocated into two groups receiving either butorphanol 0.2 mg/kg intravenously (group BUT) or fentanyl 0.01 mg/kg intravenously (group FEN). Intraocular pressure (IOP; TonoPen XL), pupil size (PUP; pupil gauge), heart rate (HR), respiratory frequency (fR) and systolic and diastolic arterial blood pressures (SAP, DAP; Cardel 9401, Midmark) were measured prior to (baseline) and at 5 and 10 minutes after drug administration (T5, T10). Data were analyzed by Shapiro Wilk, ANOVA and Mann-Whitney tests. Results: In the FEN group a significant increase of IOP was observed at T5 (P = 0,0328) and T10 (P = 0,0488). A significant decrease of PUP at T5 and T10 was detected in both, the BUT and FEN groups (P &lt; 0.05). In the FEN group HR dropped significantly at T10 (P = 0,0388), fR increased at T5 (P = 0,0340). In the BUT group SAP decreased at T5 and DAP at T5 and T10 (P &lt; 0.05). Conclusions: Within 10 minutes after administration fentanyl significantly increased intraocular pressure and decreased pupil size, butorphanol significantly decreased pupil size only. Support: Institutional founds of UVPS Brno and IGA 109/2017/FVL.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30502 - Other medical science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů