Evaluation of kaolin-activated thromboelastography and sample stability in healthy horses

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F18%3A43878393" target="_blank" >RIV/62157124:16170/18:43878393 - isvavai.cz</a>

Výsledek na webu

<a href="https://vetmed.agriculturejournals.cz/artkey/vet-201805-0001_evaluation-of-kaolin-activated-thromboelastography-and-sample-stability-in-healthy-horses.php" target="_blank" >https://vetmed.agriculturejournals.cz/artkey/vet-201805-0001_evaluation-of-kaolin-activated-thromboelastography-and-sample-stability-in-healthy-horses.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/16/2018-VETMED" target="_blank" >10.17221/16/2018-VETMED</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of kaolin-activated thromboelastography and sample stability in healthy horses

Popis výsledku v původním jazyce

Thromboelastography is an accurate alternative to routine coagulation testing for the monitoring of haemostasis. However, its use in equine medicine is limited not only by the lack of reference interval values for kaolin-activated citrated samples, but also by the limited accessibility of the test for field practitioners within the 2-hour storage time recommended by the manufacturer. To address this issue, we here evaluated kaolin-activated thromboelastography using a TEG (R) 5000 Thrombelastograph (R) Hemostasis System in 36 healthy horses, and sample stability was evaluated at four timepoints post collection in seven horses. Reference values were established as follows: reaction-time 5.0-16.0 min, K-time (period in which the clot strength reaches 20 mm of amplitude) 1.1-5.2 min, a-angle (speed of fibrin cross-linking) 36.5-79.0 degrees, maximal amplitude 44.5-69.7 mm, fibrinolysis 30 minutes after maximal amplitude was reached 0.0-2.8%. During storage, the trends in the changes of values were similar for most parameters, and values remained mostly within the reference intervals. Thromboelastography is thus useful in defining thrombohaemorrhagic complications in horses but can be sensitive to preanalytical factors and storage.

Název v anglickém jazyce

Evaluation of kaolin-activated thromboelastography and sample stability in healthy horses

Popis výsledku anglicky

Thromboelastography is an accurate alternative to routine coagulation testing for the monitoring of haemostasis. However, its use in equine medicine is limited not only by the lack of reference interval values for kaolin-activated citrated samples, but also by the limited accessibility of the test for field practitioners within the 2-hour storage time recommended by the manufacturer. To address this issue, we here evaluated kaolin-activated thromboelastography using a TEG (R) 5000 Thrombelastograph (R) Hemostasis System in 36 healthy horses, and sample stability was evaluated at four timepoints post collection in seven horses. Reference values were established as follows: reaction-time 5.0-16.0 min, K-time (period in which the clot strength reaches 20 mm of amplitude) 1.1-5.2 min, a-angle (speed of fibrin cross-linking) 36.5-79.0 degrees, maximal amplitude 44.5-69.7 mm, fibrinolysis 30 minutes after maximal amplitude was reached 0.0-2.8%. During storage, the trends in the changes of values were similar for most parameters, and values remained mostly within the reference intervals. Thromboelastography is thus useful in defining thrombohaemorrhagic complications in horses but can be sensitive to preanalytical factors and storage.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

1805-9392

Svazek periodika

63

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

203-209

Kód UT WoS článku

000433389500001

EID výsledku v databázi Scopus

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