Discard volume necessary for elimination of heparin flush effect on thromboelastography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6060" target="_blank" >RIV/00064203:_____/10:6060 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41110/10:47958 RIV/00216208:11130/10:6060

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Discard volume necessary for elimination of heparin flush effect on thromboelastography

Popis výsledku v původním jazyce

Heparin is used to prevent obstruction of indwelling arterial catheters with blood clots. It is known to affect the outcomes of analysis of coagulation parameters with thromboelastography (TEG). The aim of this study was to evaluate the minimal discard blood volume needed to eliminate the effect of heparin flush on TEG. Ten patients were included in the study. Coagulation parameters were evaluated with kaolin-activated TEG. Blood samples were obtained after discarding 1, 2, 3, 4, 5 or 10 ml of blood toeliminate the effect of heparin. We found an increase in coagulation (reflecting the heparin elimination) with the increasing discard volume between 1 and 4 ml. This was obvious from an increase in alpha angle and maximal amplitude of the measured clot and a decrease in R and time to maximal amplitude of the measured clot (P<0.001). However, values obtained after discarding 4, 5 and 10 ml of blood did not differ markedly. To obtain valid information, it is necessary to discard volume of

Název v anglickém jazyce

Discard volume necessary for elimination of heparin flush effect on thromboelastography

Popis výsledku anglicky

Heparin is used to prevent obstruction of indwelling arterial catheters with blood clots. It is known to affect the outcomes of analysis of coagulation parameters with thromboelastography (TEG). The aim of this study was to evaluate the minimal discard blood volume needed to eliminate the effect of heparin flush on TEG. Ten patients were included in the study. Coagulation parameters were evaluated with kaolin-activated TEG. Blood samples were obtained after discarding 1, 2, 3, 4, 5 or 10 ml of blood toeliminate the effect of heparin. We found an increase in coagulation (reflecting the heparin elimination) with the increasing discard volume between 1 and 4 ml. This was obvious from an increase in alpha angle and maximal amplitude of the measured clot and a decrease in R and time to maximal amplitude of the measured clot (P<0.001). However, values obtained after discarding 4, 5 and 10 ml of blood did not differ markedly. To obtain valid information, it is necessary to discard volume of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood Coagulation & Fibrinolysis

ISSN

0957-5235

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000274513600017

EID výsledku v databázi Scopus

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