Coagulation profile in bitches with pyometra: Standard tests and thromboelastography

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F25%3A43882824" target="_blank" >RIV/62157124:16170/25:43882824 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.17221/16/2025-VETMED" target="_blank" >https://doi.org/10.17221/16/2025-VETMED</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/16/2025-VETMED" target="_blank" >10.17221/16/2025-VETMED</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Coagulation profile in bitches with pyometra: Standard tests and thromboelastography

Popis výsledku v původním jazyce

This study aimed to determine coagulation changes in bitches with pyometra based on a series of coagulation tests and thromboelastography (TEG), and to assess the incidence of disseminated intravascular coagulation (DIC). Eighteen bitches with pyometra and thirty-four control bitches were examined. Haematological, biochemical, and following haemostasis parameters were measured, including: prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (AT), and levels of fibrinogen (FBG), D-dimers (DD), tissue factor (TF), plasminogen (PLG), tissue plasminogen activator inhibitor 1 (TPAI-1), and thromboelastography. DIC was considered present if three or more of these parameters were abnormal: platelet count (&lt;153 x 10(9)/l), PT (&gt;8.1 s), aPTT (&gt;25.5 s), FBG (&lt;0.6 g/l), DD (&gt;0.2 mg/l), and AT (&lt;107%). Significant differences were found in the PT, aPTT, FBG, DD, TPAI-1, clotting time, alpha-angle, and maximal amplitude. According to our scoring system, two patients were DIC positive. The study found alterations in several coagulation tests and hypercoagulable TEG tracings in bitches with pyometra, which point to excessive activation of coagulation, delayed fibrinolysis, and the presence of DIC. No patient bled abnormally, which may suggest that DIC is not overt in the majority of pyometra patients.

Název v anglickém jazyce

Coagulation profile in bitches with pyometra: Standard tests and thromboelastography

Popis výsledku anglicky

This study aimed to determine coagulation changes in bitches with pyometra based on a series of coagulation tests and thromboelastography (TEG), and to assess the incidence of disseminated intravascular coagulation (DIC). Eighteen bitches with pyometra and thirty-four control bitches were examined. Haematological, biochemical, and following haemostasis parameters were measured, including: prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin activity (AT), and levels of fibrinogen (FBG), D-dimers (DD), tissue factor (TF), plasminogen (PLG), tissue plasminogen activator inhibitor 1 (TPAI-1), and thromboelastography. DIC was considered present if three or more of these parameters were abnormal: platelet count (&lt;153 x 10(9)/l), PT (&gt;8.1 s), aPTT (&gt;25.5 s), FBG (&lt;0.6 g/l), DD (&gt;0.2 mg/l), and AT (&lt;107%). Significant differences were found in the PT, aPTT, FBG, DD, TPAI-1, clotting time, alpha-angle, and maximal amplitude. According to our scoring system, two patients were DIC positive. The study found alterations in several coagulation tests and hypercoagulable TEG tracings in bitches with pyometra, which point to excessive activation of coagulation, delayed fibrinolysis, and the presence of DIC. No patient bled abnormally, which may suggest that DIC is not overt in the majority of pyometra patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinární medicína

ISSN

0375-8427

e-ISSN

1805-9392

Svazek periodika

70

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

408-416

Kód UT WoS článku

001629381800003

EID výsledku v databázi Scopus

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