Perineural invasion of squamous cell carcinoma of the head and neck ? the beginning of the path

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Perineural invasion of squamous cell carcinoma of the head and neck ? the beginning of the path

Popis výsledku v původním jazyce

Introduction: Perineural invasion has been defined as the ability of cancer cells to invade through, in or around nerves and is clinically associated with elevated recurrence anddiminished survival. It was defined more than 100 years ago and it is morphologically describedin solid head and neck tumors, prostate, pancreatic or colorectal cancer. Only a few years ago,the attention was devoted to the factors leading to it.Material and Methods: We have retrospectively analysed cases of 532 patients with squamouscell carcinoma of head and neck in age from 33 to 86 years. In all cases, cervical block dissectionwas also perfomed with the resection of the main tumor. Patients without cervical blockdissection were excluded. All cases were paraffin embedded and 3 ?m sections were stained bymeans of the hematoxylin and eosin. The tumor size, depth of invasion, the presence andmorphology of perineural invasion and the presence of lymphangioinvasion andhemangioinvasion were evaluated.Results: From the total number of 532 cases, 70 (13,15%) cases with perineural invasion, 22(4,13%) with hemangioinvasion and 60 (11,27%) with lymphangioinvasion were encountered. Generalisation to ipsilateral lymph nodes was found in 249 (46,80%) cases, contralateralgeneralisation was present in 39 (7,33%) cases. These factors were statistically compared withfinal statistical significance. Conclusions: We focused mostly on the perineural invasion (PNI) which is probably based onthe chemotropism of tumor cells that can be stimulated by nerve tissue to further growth. The interactions between tumor and neural cells is not only limited to cell migration and tumor growth from the primary location but such interaction can also stimulate axonogenesis or extend the nerves themselves together with increasing number of axons. The subject of ourfurther study and this poster will be the analysis of changes in epithelial-mezenchymal transformation and the presence and distribution of chemoatractans of nerve tissue.

Název v anglickém jazyce

Perineural invasion of squamous cell carcinoma of the head and neck ? the beginning of the path

Popis výsledku anglicky

Introduction: Perineural invasion has been defined as the ability of cancer cells to invade through, in or around nerves and is clinically associated with elevated recurrence anddiminished survival. It was defined more than 100 years ago and it is morphologically describedin solid head and neck tumors, prostate, pancreatic or colorectal cancer. Only a few years ago,the attention was devoted to the factors leading to it.Material and Methods: We have retrospectively analysed cases of 532 patients with squamouscell carcinoma of head and neck in age from 33 to 86 years. In all cases, cervical block dissectionwas also perfomed with the resection of the main tumor. Patients without cervical blockdissection were excluded. All cases were paraffin embedded and 3 ?m sections were stained bymeans of the hematoxylin and eosin. The tumor size, depth of invasion, the presence andmorphology of perineural invasion and the presence of lymphangioinvasion andhemangioinvasion were evaluated.Results: From the total number of 532 cases, 70 (13,15%) cases with perineural invasion, 22(4,13%) with hemangioinvasion and 60 (11,27%) with lymphangioinvasion were encountered. Generalisation to ipsilateral lymph nodes was found in 249 (46,80%) cases, contralateralgeneralisation was present in 39 (7,33%) cases. These factors were statistically compared withfinal statistical significance. Conclusions: We focused mostly on the perineural invasion (PNI) which is probably based onthe chemotropism of tumor cells that can be stimulated by nerve tissue to further growth. The interactions between tumor and neural cells is not only limited to cell migration and tumor growth from the primary location but such interaction can also stimulate axonogenesis or extend the nerves themselves together with increasing number of axons. The subject of ourfurther study and this poster will be the analysis of changes in epithelial-mezenchymal transformation and the presence and distribution of chemoatractans of nerve tissue.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů