Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985904%3A_____%2F22%3A00563611" target="_blank" >RIV/67985904:_____/22:00563611 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00843989:_____/22:E0109565 RIV/00216224:14310/22:00127163 RIV/61988987:17110/22:A2302FPQ RIV/61989592:15110/22:73614995

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fgene.2022.848557/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fgene.2022.848557" target="_blank" >10.3389/fgene.2022.848557</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Popis výsledku v původním jazyce

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion's extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.

Název v anglickém jazyce

Epigenetic Regulations of Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Popis výsledku anglicky

Carcinomas of the oral cavity and oropharynx belong among the ten most common malignancies in the human population. The prognosis of head and neck squamous cell carcinoma (HNSCC) is determined by the degree of invasiveness of the primary tumor and by the extent of metastatic spread into regional and distant lymph nodes. Moreover, the level of the perineural invasion itself associates with tumor localization, invasion's extent, and the presence of nodal metastases. Here, we summarize the current knowledge about different aspects of epigenetic changes, which can be associated with HNSCC while focusing on perineural invasion (PNI). We review epigenetic modifications of the genes involved in the PNI process in HNSCC from the omics perspective and specific epigenetic modifications in OSCC or other neurotropic cancers associated with perineural invasion. Moreover, we summarize DNA methylation status of tumor-suppressor genes, methylation and demethylation enzymes and histone post-translational modifications associated with PNI. The influence of other epigenetic factors on the HNSCC incidence and perineural invasion such as tobacco, alcohol and oral microbiome is overviewed and HPV infection is discussed as an epigenetic factor associated with OSCC and related perineural invasion. Understanding epigenetic regulations of axon growth that lead to tumorous spread or uncovering the molecular control of axon interaction with cancer tissue can help to discover new therapeutic targets for these tumors.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/NV19-08-00383" target="_blank" >NV19-08-00383: Prognostické a prediktivní markery invaze spinocelulárních karcinomů dutiny ústní a orofaryngu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in genetics

ISSN

1664-8021

e-ISSN

1664-8021

Svazek periodika

13

Číslo periodika v rámci svazku

APR 27

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

20

Strana od-do

848557

Kód UT WoS článku

000875197900001

EID výsledku v databázi Scopus

2-s2.0-85130643506