Biological active compounds from Morus alba root bark
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43877665" target="_blank" >RIV/62157124:16170/19:43877665 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62157124:16370/19:43877665
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biological active compounds from Morus alba root bark
Popis výsledku v původním jazyce
In vitro biological screening of 26 mulberry constituents identified promising candidate drugs for further biological research. Antiviral, antibacterial, anti-inflammatory, and antiplasmodial activities were evaluated. Five prenylated compounds, together with a phenolic ester, proved to possess inhibitory activity against the replication of HSV-1 or HSV-2 with IC50 (EC50) values of 0.64?1.93 ?g/mL. Molecular docking studies for HSV were performed for active compounds. Several compounds exhibited significant growth inhibition of all bacterial strains tested with MICs values 1?16 ?g/mL. Furthermore, one compound was found to inhibit COX-2 with a greater activity than positive control indomethacin.
Název v anglickém jazyce
Biological active compounds from Morus alba root bark
Popis výsledku anglicky
In vitro biological screening of 26 mulberry constituents identified promising candidate drugs for further biological research. Antiviral, antibacterial, anti-inflammatory, and antiplasmodial activities were evaluated. Five prenylated compounds, together with a phenolic ester, proved to possess inhibitory activity against the replication of HSV-1 or HSV-2 with IC50 (EC50) values of 0.64?1.93 ?g/mL. Molecular docking studies for HSV were performed for active compounds. Several compounds exhibited significant growth inhibition of all bacterial strains tested with MICs values 1?16 ?g/mL. Furthermore, one compound was found to inhibit COX-2 with a greater activity than positive control indomethacin.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
10611 - Plant sciences, botany
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů