Leukocyte ratios as prognostic indicators in canine peripheral T-cell lymphoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F19%3A43878122" target="_blank" >RIV/62157124:16170/19:43878122 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Leukocyte ratios as prognostic indicators in canine peripheral T-cell lymphoma

Popis výsledku v původním jazyce

Peripheral T-cell lymphoma (PTCL) encompasses a group of aggressive lymphomas. In humans, leukocyte ratios are helpful in refining the cancer prognosis. However, for PTCL, the association of neutrophil-to-lymphocyte ratio (NLR) with inferior survival was only recently identified. No study was focused on leukocyte ratios in canine PTCL. The aim of this retrospective analysis was to evaluate NLR, neutrophil-to-eosinophil (NER), neutrophil-to-monocyte (NMR), lymphocyte-to-monocyte (LMR), eosinophil-to-monocyte (EMR) and eosinophil-to-lymphocyte (ELR) ratios as prognostic factors in canine PTCL. A total of 21 nontreated patients with pretreatment blood analysis were included. All patients were treated by chemotherapy (CHOP or LOPP). Cut-off values 3.5 for NLR, 25.0 for NER and 1.2 for LMR were set as previously published in canine lymphoma and mast cell tumour. Cut-off values 8.0 for NMR, 0.1 for EMR and 0.11 for ELR were previously reported in human studies. All ratios were independent from age, weight, sex, lymphoma grade, stage or substage. Initial treatment response was negatively linked to high NER (p=0.002) and low ELR (p=0.03). No differences in progression-free survival (PFS) nor lymphoma-specific survival (LSS) were observed in NLR, LMR, EMR or NMR. High NER was associated with inferior PFS (43 vs. 152 days, p=0.004) and LSS (94 vs. 210 days, p=0.03). Low ELR was linked to shorter PFS (33 vs. 144 days, p=0.003) and LSS (68 vs. 205 days, p=0.004). In our group of PTCL patients only NER and ELR indicated inferior survival. However larger prospective studies on different WHO lymphoma types with standardized treatment protocol are warranted.

Název v anglickém jazyce

Leukocyte ratios as prognostic indicators in canine peripheral T-cell lymphoma

Popis výsledku anglicky

Peripheral T-cell lymphoma (PTCL) encompasses a group of aggressive lymphomas. In humans, leukocyte ratios are helpful in refining the cancer prognosis. However, for PTCL, the association of neutrophil-to-lymphocyte ratio (NLR) with inferior survival was only recently identified. No study was focused on leukocyte ratios in canine PTCL. The aim of this retrospective analysis was to evaluate NLR, neutrophil-to-eosinophil (NER), neutrophil-to-monocyte (NMR), lymphocyte-to-monocyte (LMR), eosinophil-to-monocyte (EMR) and eosinophil-to-lymphocyte (ELR) ratios as prognostic factors in canine PTCL. A total of 21 nontreated patients with pretreatment blood analysis were included. All patients were treated by chemotherapy (CHOP or LOPP). Cut-off values 3.5 for NLR, 25.0 for NER and 1.2 for LMR were set as previously published in canine lymphoma and mast cell tumour. Cut-off values 8.0 for NMR, 0.1 for EMR and 0.11 for ELR were previously reported in human studies. All ratios were independent from age, weight, sex, lymphoma grade, stage or substage. Initial treatment response was negatively linked to high NER (p=0.002) and low ELR (p=0.03). No differences in progression-free survival (PFS) nor lymphoma-specific survival (LSS) were observed in NLR, LMR, EMR or NMR. High NER was associated with inferior PFS (43 vs. 152 days, p=0.004) and LSS (94 vs. 210 days, p=0.03). Low ELR was linked to shorter PFS (33 vs. 144 days, p=0.003) and LSS (68 vs. 205 days, p=0.004). In our group of PTCL patients only NER and ELR indicated inferior survival. However larger prospective studies on different WHO lymphoma types with standardized treatment protocol are warranted.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů