Influence of methadone on intraocular pressure, pupil size and aqueous tear production in healthy dogs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16170%2F22%3A43879946" target="_blank" >RIV/62157124:16170/22:43879946 - isvavai.cz</a>

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S1938973622001064?token=FE27FA7E26D800F86AF14DB2D5FD364BEB3B1E2A0A2B0502811EE4FC8534D76A32B37C18996944026DACE18B1C2D0C6D&originRegion=eu-west-1&originCreation=20230113132439" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1938973622001064?token=FE27FA7E26D800F86AF14DB2D5FD364BEB3B1E2A0A2B0502811EE4FC8534D76A32B37C18996944026DACE18B1C2D0C6D&originRegion=eu-west-1&originCreation=20230113132439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tcam.2022.100733" target="_blank" >10.1016/j.tcam.2022.100733</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of methadone on intraocular pressure, pupil size and aqueous tear production in healthy dogs

Popis výsledku v původním jazyce

Intraocular pressure (IOP), pupil size (PS), and tear production are variables important in maintaining eye homeostasis.The purpose of this study was to determine the effects of methadone on IOP, PS, and tear production measured by Schirmer I tear test (STT-I) in healthy nonpainful dogs. A prospective, randomized, &quot;double-blind&quot; clinical study was performed. A total of 40 healthy conscious client-owned dogs were included in the study. Dogs were allocated randomly to 1 of 3 groups and given intravenous methadone 0.3 mg/kg (Met-IV, n=15), intramuscular methadone 0.3 mg/kg (Met-IM, n = 15), or saline 0.3 mL/kg (SAL, n = 10). IOP, PS, STT-I, heart rate (HR), and mean arterial pressure (MAP) weremeasured prior to (baseline) and at 2, 5, 10, 20, and 30 minutes after drug administration. Data were analyzed using 1-way and 2-way repeatedmeasures ANOVA or their nonparametric equivalents (P &lt; .05). No significant differences in IOP and PS within or between the groups were detected. In the Met-IV group, the STT-I decreased significantly after 30minutes (P = .025), however, the values remained within the physiological ranges. In Met-IV group, HR decreased significantly at 5, 10, 20, and 30 minutes, respectively. No other significant differences were observed.Methadone administered at a dose of 0.3 mg/kg intravenously or intramuscularly seems to cause within 30minutes no clinically important effect on IOP, PS, and STT-I in healthy conscious nonpainful dogs without ocular abnormalities.

Název v anglickém jazyce

Influence of methadone on intraocular pressure, pupil size and aqueous tear production in healthy dogs

Popis výsledku anglicky

Intraocular pressure (IOP), pupil size (PS), and tear production are variables important in maintaining eye homeostasis.The purpose of this study was to determine the effects of methadone on IOP, PS, and tear production measured by Schirmer I tear test (STT-I) in healthy nonpainful dogs. A prospective, randomized, &quot;double-blind&quot; clinical study was performed. A total of 40 healthy conscious client-owned dogs were included in the study. Dogs were allocated randomly to 1 of 3 groups and given intravenous methadone 0.3 mg/kg (Met-IV, n=15), intramuscular methadone 0.3 mg/kg (Met-IM, n = 15), or saline 0.3 mL/kg (SAL, n = 10). IOP, PS, STT-I, heart rate (HR), and mean arterial pressure (MAP) weremeasured prior to (baseline) and at 2, 5, 10, 20, and 30 minutes after drug administration. Data were analyzed using 1-way and 2-way repeatedmeasures ANOVA or their nonparametric equivalents (P &lt; .05). No significant differences in IOP and PS within or between the groups were detected. In the Met-IV group, the STT-I decreased significantly after 30minutes (P = .025), however, the values remained within the physiological ranges. In Met-IV group, HR decreased significantly at 5, 10, 20, and 30 minutes, respectively. No other significant differences were observed.Methadone administered at a dose of 0.3 mg/kg intravenously or intramuscularly seems to cause within 30minutes no clinically important effect on IOP, PS, and STT-I in healthy conscious nonpainful dogs without ocular abnormalities.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Topics in Companion Animal Medicine

ISSN

1938-9736

e-ISSN

1946-9837

Svazek periodika

51

Číslo periodika v rámci svazku

NOV 2022

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

1-4

Kód UT WoS článku

000916654300007

EID výsledku v databázi Scopus

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