Limitations of the current equine melanocytic tumour classification

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Limitations of the current equine melanocytic tumour classification

Popis výsledku v původním jazyce

Equine melanocytic tumours (EMT) are frequent in older grey horses. They are described as variously pigmented neoplasia, mainly located on the ventral tail and in the perineum, which can progress into generalised disease. Histopathologically, EMT can be divided into four types: melanocytic nevus (MN), dermal melanoma/melanomatosis (DM/DMT) and anaplastic malignant melanoma (AMM). However, recent studies suggest that this classification does not sufficiently reflect the biological behaviour of these tumours. This study aimed to classify EMTs diagnosed by routine HE staining with the aid of immunohistochemistry. EMTs from thirty horses were examined. The majority of the affected horses were grey, only three had other coat colours (black, perlino, chestnut). Twelve EMTs were classified as DM/DMT, eleven as MN and two as AMM. Five cases could not be classified. They originated from three horses with a single or multiple tumours which showed characteristics of both MN and DM/DMT and two horses in the early stage of the disease. The relatively high proportion of unclassified EMTs (3 out of 30 cases, 10%) indicate the need for improving/extending of the current classification.

Název v anglickém jazyce

Limitations of the current equine melanocytic tumour classification

Popis výsledku anglicky

Equine melanocytic tumours (EMT) are frequent in older grey horses. They are described as variously pigmented neoplasia, mainly located on the ventral tail and in the perineum, which can progress into generalised disease. Histopathologically, EMT can be divided into four types: melanocytic nevus (MN), dermal melanoma/melanomatosis (DM/DMT) and anaplastic malignant melanoma (AMM). However, recent studies suggest that this classification does not sufficiently reflect the biological behaviour of these tumours. This study aimed to classify EMTs diagnosed by routine HE staining with the aid of immunohistochemistry. EMTs from thirty horses were examined. The majority of the affected horses were grey, only three had other coat colours (black, perlino, chestnut). Twelve EMTs were classified as DM/DMT, eleven as MN and two as AMM. Five cases could not be classified. They originated from three horses with a single or multiple tumours which showed characteristics of both MN and DM/DMT and two horses in the early stage of the disease. The relatively high proportion of unclassified EMTs (3 out of 30 cases, 10%) indicate the need for improving/extending of the current classification.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

40301 - Veterinary science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů