Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870591" target="_blank" >RIV/62157124:16270/11:43870591 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/11:00002495 RIV/62157124:16170/11:43870591

Výsledek na webu

<a href="http://dx.doi.org/10.1186/1751-0147-53-2" target="_blank" >http://dx.doi.org/10.1186/1751-0147-53-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/1751-0147-53-2" target="_blank" >10.1186/1751-0147-53-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model

Popis výsledku v původním jazyce

Background: The aim of the present study was to investigate biochemical and oxidative stress responses to experimental F. tularensis infection in European brown hares, an important source of human tularemia infections. Methods: For these purposes we compared the development of an array of biochemical parameters measured in blood plasma using standard procedures of dry chemistry as well as electrochemical devices following a subcutaneous infection with a wild Francisella tularensis subsp. holarctica strain (a single dose of 2.6 x 109 CFU pro toto). Results: Subcutaneous inoculation of a single dose with 2.6 x 109 colony forming units of a wild F. tularensis strain pro toto resulted in the death of two out of five hares. Plasma chemistry profiles were examined on days 2 to 35 post-infection. When compared to controls, the total protein, urea, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase were increased, while albumin, glucose and amylase were decreased. B

Název v anglickém jazyce

Biochemical responses and oxidative stress in Francisella tularensis infection: a European brown hare model

Popis výsledku anglicky

Background: The aim of the present study was to investigate biochemical and oxidative stress responses to experimental F. tularensis infection in European brown hares, an important source of human tularemia infections. Methods: For these purposes we compared the development of an array of biochemical parameters measured in blood plasma using standard procedures of dry chemistry as well as electrochemical devices following a subcutaneous infection with a wild Francisella tularensis subsp. holarctica strain (a single dose of 2.6 x 109 CFU pro toto). Results: Subcutaneous inoculation of a single dose with 2.6 x 109 colony forming units of a wild F. tularensis strain pro toto resulted in the death of two out of five hares. Plasma chemistry profiles were examined on days 2 to 35 post-infection. When compared to controls, the total protein, urea, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase were increased, while albumin, glucose and amylase were decreased. B

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Veterinaria Scandinavica

ISSN

0044-605X

e-ISSN

—

Svazek periodika

53

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

13

Strana od-do

1-13

Kód UT WoS článku

000286595500001

EID výsledku v databázi Scopus

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