Sublethal exposure of European brown hares to an anticholinesterase agent paraoxon modulates the course of tularemia

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sublethal exposure of European brown hares to an anticholinesterase agent paraoxon modulates the course of tularemia

Popis výsledku v původním jazyce

The aim of the present study was to test the hypothesis that sublethal exposure to pesticides increases the susceptibility of hares to F. tularensis and modulates the course of the infection. Experimental hares were allocated to a) control, b) paraoxon-treated, c) F. tularensis-treated, and d) paraoxon-and-F. tularensis-treated groups of five specimens on a random basis and subcutaneously inoculated with a wild F. tularensis subsp. holarctica strain (a single dose of 9 x 108 CFU pro toto) and/or injected a sublethal dose of paraoxon (100 mýg/kg). The paraoxon-and-F. tularensis-treated group showed a rapid onset of clinical signs and all deaths occurred on days 2 and 3 post exposure. F. tularensis-inoculated hares survived from 3 to 10 days, while onlyone hare died on day 12 in the paraoxon-treated group. Survival curves in the three exposé groups were significantly different from the control and median survival in F. tularensis-inoculated and paraoxon-and-F. tularensis-treated hares a

Název v anglickém jazyce

Sublethal exposure of European brown hares to an anticholinesterase agent paraoxon modulates the course of tularemia

Popis výsledku anglicky

The aim of the present study was to test the hypothesis that sublethal exposure to pesticides increases the susceptibility of hares to F. tularensis and modulates the course of the infection. Experimental hares were allocated to a) control, b) paraoxon-treated, c) F. tularensis-treated, and d) paraoxon-and-F. tularensis-treated groups of five specimens on a random basis and subcutaneously inoculated with a wild F. tularensis subsp. holarctica strain (a single dose of 9 x 108 CFU pro toto) and/or injected a sublethal dose of paraoxon (100 mýg/kg). The paraoxon-and-F. tularensis-treated group showed a rapid onset of clinical signs and all deaths occurred on days 2 and 3 post exposure. F. tularensis-inoculated hares survived from 3 to 10 days, while onlyone hare died on day 12 in the paraoxon-treated group. Survival curves in the three exposé groups were significantly different from the control and median survival in F. tularensis-inoculated and paraoxon-and-F. tularensis-treated hares a

Druh

D - Stať ve sborníku

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of scientific contributions and abstracts Infectious and Parasitic Diseases of Animals

ISBN

978-80-8077-230-7

ISSN

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e-ISSN

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Počet stran výsledku

3

Strana od-do

113-115

Název nakladatele

Univerzita veterinárného lekárstva Košice

Místo vydání

Košice

Místo konání akce

Košice

Datum konání akce

7. 9. 2011

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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