Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F11%3A43870599" target="_blank" >RIV/62157124:16270/11:43870599 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/11:00002467
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
Popis výsledku v původním jazyce
Objective: The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats. Background: Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE). Treatment is typically based on application of atropine and oxime reactivator. Atropine is able to protect overstimulation of muscarinic acetylcholine receptors. Application of oxime reactivator enable return of AChE activity and full suppression of intoxication. Methods: In a total, fifteen biochemical markers were assayed in plasma or blood of intoxicated animals. 42 rats were divided into 7 groups each 6 individuals. The first group was exposed to atropine; thesecond group was exposed to one LD(50) of soman and atropine. The groups 3 - 5 were exposed in a same way as the second group and were treated with oxime reactivators: HI-6 (group 3), trimedoxime (4) and K203 (5). The sixth group was con
Název v anglickém jazyce
Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model
Popis výsledku anglicky
Objective: The present experiment is based on biochemical assessment of nerve agent soman intoxication and atropine, respectively atropine and HI-6, trimedoxime or K203 treatment in rats. Background: Nerve agents are toxic substances irreversibly inhibiting enzyme acetylcholinesterase (AChE). Treatment is typically based on application of atropine and oxime reactivator. Atropine is able to protect overstimulation of muscarinic acetylcholine receptors. Application of oxime reactivator enable return of AChE activity and full suppression of intoxication. Methods: In a total, fifteen biochemical markers were assayed in plasma or blood of intoxicated animals. 42 rats were divided into 7 groups each 6 individuals. The first group was exposed to atropine; thesecond group was exposed to one LD(50) of soman and atropine. The groups 3 - 5 were exposed in a same way as the second group and were treated with oxime reactivators: HI-6 (group 3), trimedoxime (4) and K203 (5). The sixth group was con
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bratislava Medical Journal-Bratislavske Lekarske Listy
ISSN
0006-9248
e-ISSN
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Svazek periodika
112
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
6
Strana od-do
539-544
Kód UT WoS článku
000294514400001
EID výsledku v databázi Scopus
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