Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6)
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871455" target="_blank" >RIV/62157124:16270/12:43871455 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60162694:G44__/12:43874621
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6)
Popis výsledku v původním jazyce
Objective: Francisella tularensis is an intracellular pathogen causing tularemia disease. Immune system action against tularemia is limited due to lipopolysaccharide covering bacterial cell. Cholinergic anti-inflammatory pathway is a link between parasympathetic nervous system and macrophage assisted immunity. Asoxime (also known as HI-6) is a compound implicated in regulation of acetylcholinesterase as well as acetylcholine receptors. We hypothesize suitability of asoxime to modulate tularemia progression. Procedure and experiment design: Laboratory mice BALB/c were infected with F. tularensis LVS strain and challenged by application of 209 mu g/kg to 209 mg/kg of HI-6 in the experiment beginning and then the next day. Mice were sacrificed after fivedays. Plasma, spleen and liver were sampled. In the separate experiment, tularemia caused mortality was assessed with and without of asoxime application. Results and Conclusions: Regarding to oxidative damage of liver and spleen, asoxime
Název v anglickém jazyce
Tularemia Progression and it Modulation Including Mortality Remission and Enhancing of Immune System Response Using Asoxime (HI-6)
Popis výsledku anglicky
Objective: Francisella tularensis is an intracellular pathogen causing tularemia disease. Immune system action against tularemia is limited due to lipopolysaccharide covering bacterial cell. Cholinergic anti-inflammatory pathway is a link between parasympathetic nervous system and macrophage assisted immunity. Asoxime (also known as HI-6) is a compound implicated in regulation of acetylcholinesterase as well as acetylcholine receptors. We hypothesize suitability of asoxime to modulate tularemia progression. Procedure and experiment design: Laboratory mice BALB/c were infected with F. tularensis LVS strain and challenged by application of 209 mu g/kg to 209 mg/kg of HI-6 in the experiment beginning and then the next day. Mice were sacrificed after fivedays. Plasma, spleen and liver were sampled. In the separate experiment, tularemia caused mortality was assessed with and without of asoxime application. Results and Conclusions: Regarding to oxidative damage of liver and spleen, asoxime
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
GJ - Choroby a škůdci zvířat, veterinární medicina
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International journal of applied research in veterinary medicine
ISSN
1542-2666
e-ISSN
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Svazek periodika
10
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
76-84
Kód UT WoS článku
000302334100011
EID výsledku v databázi Scopus
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