Effects of subchronic exposure of diclofenac on growth, histopathological changes, and oxidative stress in zebrafish (Danio rerio)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872821" target="_blank" >RIV/62157124:16270/14:43872821 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/14:43872821

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/645737" target="_blank" >http://dx.doi.org/10.1155/2014/645737</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/645737" target="_blank" >10.1155/2014/645737</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of subchronic exposure of diclofenac on growth, histopathological changes, and oxidative stress in zebrafish (Danio rerio)

Popis výsledku v původním jazyce

The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes in Danio rerio. The juvenile growth tests were performed on Danio rerio according to OECDmethod number 215. Fish at the age of 20 days were exposed to the diclofenac environmental concentration commonly detected in the Czech rivers (0.02 mg L-1) and the range of sublethal concentrations of diclofenac (5, 15, 30, and 60 mg L-1) for 28 days.A significant decrease (P { 0.01) in the fish growth caused by diclofenac was observed in the concentrations of 30 and 60 mg L-1. The identified value of LOEC (lowest observed effect concentration) was 15 mg L-1 of diclofenac and NOEC (no observed effectconcentration) value was 5 mg L-1 of diclofenac. We did not find histopathological changes and changes of selected parameters of oxidative stress (glutathione S-transferase, glutathione reductase) in tested fish. The environmental concen

Název v anglickém jazyce

Effects of subchronic exposure of diclofenac on growth, histopathological changes, and oxidative stress in zebrafish (Danio rerio)

Popis výsledku anglicky

The aim of this study was to investigate effects of subchronic exposure to sublethal levels of diclofenac on growth, oxidative stress, and histopathological changes in Danio rerio. The juvenile growth tests were performed on Danio rerio according to OECDmethod number 215. Fish at the age of 20 days were exposed to the diclofenac environmental concentration commonly detected in the Czech rivers (0.02 mg L-1) and the range of sublethal concentrations of diclofenac (5, 15, 30, and 60 mg L-1) for 28 days.A significant decrease (P { 0.01) in the fish growth caused by diclofenac was observed in the concentrations of 30 and 60 mg L-1. The identified value of LOEC (lowest observed effect concentration) was 15 mg L-1 of diclofenac and NOEC (no observed effectconcentration) value was 5 mg L-1 of diclofenac. We did not find histopathological changes and changes of selected parameters of oxidative stress (glutathione S-transferase, glutathione reductase) in tested fish. The environmental concen

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific World Journal

ISSN

1537-744X

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

2014

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

"nestrankovano"

Kód UT WoS článku

000331475000001

EID výsledku v databázi Scopus

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