Oxidative stress and liver damage in birds exposed to diclofenac and lead

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872898" target="_blank" >RIV/62157124:16270/14:43872898 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/14:43875309 RIV/62157124:16170/14:43872898

Výsledek na webu

<a href="http://dx.doi.org/10.2754/avb201483040299" target="_blank" >http://dx.doi.org/10.2754/avb201483040299</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb201483040299" target="_blank" >10.2754/avb201483040299</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oxidative stress and liver damage in birds exposed to diclofenac and lead

Popis výsledku v původním jazyce

Responses of wildlife to multiple stressors fit in the ecological concept of trade-off. While toxicity of non-steroidal anti-inflammatory drugs and heavy metals for free-ranging birds has been shown in single exposures, the present study aims to evaluateoxidative stress, and liver and kidney damage caused by single and combined effects of diclofenac and lead in the Japanese quail. Forty Japanese quail (Coturnix coturnix japonica) were divided into equal groups of controls, diclofenac, Pb, and Pb+diclofenac exposures. The birds were exposed to the respective chemicals through insertion of lead shots (1.5 g) into the crop on day 0 of the experiment and/ or administration of 5 mg/kg of diclofenac intramuscularly in two treatments on days 0 and 5. Groupsin liver and kidney tissues of birds were then compared after 10 days using histopathology and biochemistry markers such as glutathione reductase (GR), ferric reducing antioxidant power (FRAP), and lipid peroxidation measured as total thi

Název v anglickém jazyce

Oxidative stress and liver damage in birds exposed to diclofenac and lead

Popis výsledku anglicky

Responses of wildlife to multiple stressors fit in the ecological concept of trade-off. While toxicity of non-steroidal anti-inflammatory drugs and heavy metals for free-ranging birds has been shown in single exposures, the present study aims to evaluateoxidative stress, and liver and kidney damage caused by single and combined effects of diclofenac and lead in the Japanese quail. Forty Japanese quail (Coturnix coturnix japonica) were divided into equal groups of controls, diclofenac, Pb, and Pb+diclofenac exposures. The birds were exposed to the respective chemicals through insertion of lead shots (1.5 g) into the crop on day 0 of the experiment and/ or administration of 5 mg/kg of diclofenac intramuscularly in two treatments on days 0 and 5. Groupsin liver and kidney tissues of birds were then compared after 10 days using histopathology and biochemistry markers such as glutathione reductase (GR), ferric reducing antioxidant power (FRAP), and lipid peroxidation measured as total thi

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

—

Svazek periodika

83

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

299-304

Kód UT WoS článku

000346604900004

EID výsledku v databázi Scopus

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