Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F14%3A43872947" target="_blank" >RIV/62157124:16270/14:43872947 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/14:43907785

Výsledek na webu

<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >http://dx.doi.org/10.3892/ol.2014.1912</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/ol.2014.1912" target="_blank" >10.3892/ol.2014.1912</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry

Popis výsledku v původním jazyce

Estrogen receptors [ERs (subtypes alfa and beta)], clas?sified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepres?sors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ERalfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influ?ence on

Název v anglickém jazyce

Identification of estrogen receptor proteins in breast cancer cells using matrix-assisted laser desorption/ionization time of flight mass spectrometry

Popis výsledku anglicky

Estrogen receptors [ERs (subtypes alfa and beta)], clas?sified as a nuclear receptor super family, are intracellular proteins with an important biological role as the transcription factors for estrogen target genes. For ER induced transcription, an interaction must exist between ligand and coregulators. Coregulators may stimulate (coactivators) or inhibit (corepres?sors) transcription, following binding with a specific region of the gene, called the estrogen response element. Misbalanced activity of coregulators or higher ligand concentrations may cause increased cell proliferation, resulting in specific types of cancer. These are exhibited as overexpression of ER proteins. Breast cancer currently ranks first in the incidence and second in the mortality of cancer in females worldwide. In addition, 70% of breast tumors are ERalfa positive and the importance of these proteins for diagnostic use is indisputable. Early diagnosis of the tumor and its classification has a large influ?ence on

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oncology letters

ISSN

1792-1074

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

4

Strana od-do

1341-1344

Kód UT WoS článku

000337558000003

EID výsledku v databázi Scopus

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