Lipolytické a hypolipidemické vlastnosti nově syntetizovaných aryloxyaminopropanolů.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F08%3A00002048" target="_blank" >RIV/62157124:16370/08:00002048 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Lipolytic and Hypolipidemic Properties of newly Synthesized Aryloxypropanolamine Derivates.

Popis výsledku v původním jazyce

In this study, the lipolytic effect of two newly synthesized potential ?3-adrenergic agonists A482 and B496 in active acid forms was tested using isolated sliced epididymal adipose tissue of Wistar rats, and compared with Isoprenaline and BRL37344. Furthermore, effects of an eight-week oral administration of the newly synthesized substances on serum cholesterol, triglycerides, glucose, adiponectin, resistin and weight gain were studied in C57Bl/6J mice that were fed high energy diet. The newly synthesized substance A482 (4-(2-{[2-hydroxy-3-(4-methyl-carbamoylphenoxy) propyl]amino}ethyl)phenoxy-acetic acid hydrochloride) was able to produce almost full lipolysis at a 1 x 10-7 M concentration, and its effect on the rat epididymal adipose tissue was similar to the specific ?3-adrenergic agonist BRL37344. Ethyl ester of this substance significantly lowered plasma total cholesterol (p < 0.001), resistin (p < 0.01), weight gain (p < 0.01), improved total/HDL-cholesterol ratio (p < 0.01

Název v anglickém jazyce

Lipolytic and Hypolipidemic Properties of newly Synthesized Aryloxypropanolamine Derivates.

Popis výsledku anglicky

In this study, the lipolytic effect of two newly synthesized potential ?3-adrenergic agonists A482 and B496 in active acid forms was tested using isolated sliced epididymal adipose tissue of Wistar rats, and compared with Isoprenaline and BRL37344. Furthermore, effects of an eight-week oral administration of the newly synthesized substances on serum cholesterol, triglycerides, glucose, adiponectin, resistin and weight gain were studied in C57Bl/6J mice that were fed high energy diet. The newly synthesized substance A482 (4-(2-{[2-hydroxy-3-(4-methyl-carbamoylphenoxy) propyl]amino}ethyl)phenoxy-acetic acid hydrochloride) was able to produce almost full lipolysis at a 1 x 10-7 M concentration, and its effect on the rat epididymal adipose tissue was similar to the specific ?3-adrenergic agonist BRL37344. Ethyl ester of this substance significantly lowered plasma total cholesterol (p < 0.001), resistin (p < 0.01), weight gain (p < 0.01), improved total/HDL-cholesterol ratio (p < 0.01

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria Brno

ISSN

0001-7213

e-ISSN

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Svazek periodika

77

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000263226200014

EID výsledku v databázi Scopus

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