Electrochemical investigation of strontium - metallothionein interactions - analysis of serum and urine of patients with osteoporosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F09%3A00002085" target="_blank" >RIV/62157124:16370/09:00002085 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00064203:_____/09:5147 RIV/00216208:11130/09:5147 RIV/00023001:_____/09:00002757

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical investigation of strontium - metallothionein interactions - analysis of serum and urine of patients with osteoporosis

Popis výsledku v původním jazyce

The main aim of this paper is to study interaction between strontium and metallothionein (MT), and to determine changes in strontium and thiols (MT, reduced glutathione, cysteine, and homocysteine) level in plasma, serum, and urine samples of patients treated with strontium ranelate (SrR). To investigate the interactions between MT and strontium(II) ions, adsorptive transfer stripping technique coupled with differential pulse voltammetry (DPV) the Brdicka reaction was employed. Besides standard Brdickasignals (Co, RS 2Co, Cat1, Cat2, Cat3), we observed new signal related to Sr-MT interaction. Further we investigated the effect of various time of interaction, concentration of strontium(II) ions and temperature of supporting electrolyte on Brdicka signals. Optimal time of interaction was 240 s. Under temperature of supporting electrolyte 20 °C, we measured linear dependence of Cat3 signal height on strontium(II) ions concentration. After that we have investigated the possibility of stro

Název v anglickém jazyce

Electrochemical investigation of strontium - metallothionein interactions - analysis of serum and urine of patients with osteoporosis

Popis výsledku anglicky

The main aim of this paper is to study interaction between strontium and metallothionein (MT), and to determine changes in strontium and thiols (MT, reduced glutathione, cysteine, and homocysteine) level in plasma, serum, and urine samples of patients treated with strontium ranelate (SrR). To investigate the interactions between MT and strontium(II) ions, adsorptive transfer stripping technique coupled with differential pulse voltammetry (DPV) the Brdicka reaction was employed. Besides standard Brdickasignals (Co, RS 2Co, Cat1, Cat2, Cat3), we observed new signal related to Sr-MT interaction. Further we investigated the effect of various time of interaction, concentration of strontium(II) ions and temperature of supporting electrolyte on Brdicka signals. Optimal time of interaction was 240 s. Under temperature of supporting electrolyte 20 °C, we measured linear dependence of Cat3 signal height on strontium(II) ions concentration. After that we have investigated the possibility of stro

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/IAA401990701" target="_blank" >IAA401990701: Studium vazby platinových cytostatik do struktury DNA; Vliv metalothioneinu</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Electroanalysis

ISSN

1040-0397

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

3-5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

000264063500059

EID výsledku v databázi Scopus

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