Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F11%3A43870761" target="_blank" >RIV/62157124:16370/11:43870761 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid
Popis výsledku v původním jazyce
In a solution containing 0.067% methylparaben, 0.033% propylparaben, 3.4% glycerol and 2.0% boric acid, concentrations of both parabens, 4-hydroxybenzoic acid and 2,3-dihydroxypropyl 4-hydroxybenzoate were monitored for up to 68 months storage. 4-hydroxybenzoic acid is the main hydrolysis product of parabens, while 2,3-dihydroxypropyl 4-hydroxybenzoate was proposed as the main product of transesterification of parabens with glycerol. Results of an HPLC evaluation of parabens, 4-hydroxybenzoic acid and 2,3- dihydroxypropyl 4-hydroxybenzoate showed that the decomposition of 68 months old samples stored at room temperature did not exceed 2.0%. The stability of both parabens in a medicinal preparation of the stated composition has thus been satisfactorilydemonstrated after more than 5 years of storage under ambient conditions. The transesterification reaction was shown to influence the chemical stability of parabens to an extent comparable to hydrolysis. Moreover, the presence of 2,3-dihy
Název v anglickém jazyce
Hydrolysis and transesterification of parabens in an aqueous solution in the presence of glycerol and boric acid
Popis výsledku anglicky
In a solution containing 0.067% methylparaben, 0.033% propylparaben, 3.4% glycerol and 2.0% boric acid, concentrations of both parabens, 4-hydroxybenzoic acid and 2,3-dihydroxypropyl 4-hydroxybenzoate were monitored for up to 68 months storage. 4-hydroxybenzoic acid is the main hydrolysis product of parabens, while 2,3-dihydroxypropyl 4-hydroxybenzoate was proposed as the main product of transesterification of parabens with glycerol. Results of an HPLC evaluation of parabens, 4-hydroxybenzoic acid and 2,3- dihydroxypropyl 4-hydroxybenzoate showed that the decomposition of 68 months old samples stored at room temperature did not exceed 2.0%. The stability of both parabens in a medicinal preparation of the stated composition has thus been satisfactorilydemonstrated after more than 5 years of storage under ambient conditions. The transesterification reaction was shown to influence the chemical stability of parabens to an extent comparable to hydrolysis. Moreover, the presence of 2,3-dihy
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Excipients and Food Chemicals
ISSN
2150-2668
e-ISSN
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Svazek periodika
2
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
41-49
Kód UT WoS článku
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EID výsledku v databázi Scopus
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