Polymorphism G - 308A in the Promoter of the Tumor Necrosis Factor-alfa gene and Its Association with the Risk of Venous Thromboembolism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871394" target="_blank" >RIV/62157124:16370/12:43871394 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1097/MBC.0b013e3283527506" target="_blank" >http://dx.doi.org/10.1097/MBC.0b013e3283527506</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MBC.0b013e3283527506" target="_blank" >10.1097/MBC.0b013e3283527506</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymorphism G - 308A in the Promoter of the Tumor Necrosis Factor-alfa gene and Its Association with the Risk of Venous Thromboembolism

Popis výsledku v původním jazyce

The main abnormalities associated with the increased risk of venous thrombosis (VT) are the inherited deficiencies of antithrombin, protein C, protein S, the point mutations known as factor V Leiden (FVL) and factor II (FII) G20210A. The association of other specific genes with thrombotic risk is less known. G-308A polymorphism in the promoter area of the gene coding for tumor necrosis factor alpha (TNF-alfa) is associated with an increased transcription activity of this gene, increased TNF-alfa production and subsequent predisposition to some illnesses. The aim of this work was to study the link between this polymorphism and predisposition to deep venous thrombosis. The research determined the frequency of the variant allele -308A in the gene for TNF-alfa in a group of 67 patients diagnosed with deep venous thrombosis and in a group of 62 healthy volunteers. We confirmed statistically significant link between the occurrence of the variant allele -308A and deep venous thrombosis (P = 0

Název v anglickém jazyce

Polymorphism G - 308A in the Promoter of the Tumor Necrosis Factor-alfa gene and Its Association with the Risk of Venous Thromboembolism

Popis výsledku anglicky

The main abnormalities associated with the increased risk of venous thrombosis (VT) are the inherited deficiencies of antithrombin, protein C, protein S, the point mutations known as factor V Leiden (FVL) and factor II (FII) G20210A. The association of other specific genes with thrombotic risk is less known. G-308A polymorphism in the promoter area of the gene coding for tumor necrosis factor alpha (TNF-alfa) is associated with an increased transcription activity of this gene, increased TNF-alfa production and subsequent predisposition to some illnesses. The aim of this work was to study the link between this polymorphism and predisposition to deep venous thrombosis. The research determined the frequency of the variant allele -308A in the gene for TNF-alfa in a group of 67 patients diagnosed with deep venous thrombosis and in a group of 62 healthy volunteers. We confirmed statistically significant link between the occurrence of the variant allele -308A and deep venous thrombosis (P = 0

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood coagulation & fibrinolysis

ISSN

0957-5235

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

316-319

Kód UT WoS článku

000303655600012

EID výsledku v databázi Scopus

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