Gene Polymorphsms and Inflammatory Bowel Diseases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871453" target="_blank" >RIV/62157124:16370/12:43871453 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.5772/53465" target="_blank" >http://dx.doi.org/10.5772/53465</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5772/53465" target="_blank" >10.5772/53465</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Gene Polymorphsms and Inflammatory Bowel Diseases
Popis výsledku v původním jazyce
The etiopathogenesis of inflammatory bowel diseases is not fully understood to date. However, several studies have confirmed that there are external factors, together with genetic predisposition, which contribute to the diseases' onset. Genes whose products somehow influence the development of the inflammatory reaction are called "candidate genes". At present, the correlation between the genetic constitution of an individual and the predisposition to disease has been studied as well as its connection with the clinical characteristic of a disease (e.g. NOD2/CARD15, ICAM-1, CCR5, MDR1, TLR4 genes). IBD therapy is lengthy; therefore it requires an individual choice of a drug with an aim to reduce or eliminate adverse effects. The presence of variant alleles of polymorphisms in "therapeutic genes" can be of significant help in predicting the adverse effects of a given therapy. The relationship between myelosupression and the presence of variant alleles in the gene for TPMT is of the greate
Název v anglickém jazyce
Gene Polymorphsms and Inflammatory Bowel Diseases
Popis výsledku anglicky
The etiopathogenesis of inflammatory bowel diseases is not fully understood to date. However, several studies have confirmed that there are external factors, together with genetic predisposition, which contribute to the diseases' onset. Genes whose products somehow influence the development of the inflammatory reaction are called "candidate genes". At present, the correlation between the genetic constitution of an individual and the predisposition to disease has been studied as well as its connection with the clinical characteristic of a disease (e.g. NOD2/CARD15, ICAM-1, CCR5, MDR1, TLR4 genes). IBD therapy is lengthy; therefore it requires an individual choice of a drug with an aim to reduce or eliminate adverse effects. The presence of variant alleles of polymorphisms in "therapeutic genes" can be of significant help in predicting the adverse effects of a given therapy. The relationship between myelosupression and the presence of variant alleles in the gene for TPMT is of the greate
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
FE - Ostatní obory vnitřního lékařství
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Inflammatory bowel disease
ISBN
978-953-51-0879-5
Počet stran výsledku
49
Strana od-do
"23?71"
Počet stran knihy
282
Název nakladatele
InTech
Místo vydání
Rijeka, Chorvatsko
Kód UT WoS kapitoly
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