Application of constrained real-space refinement of flexible molecular fragments to automatic model building of RNA structures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F12%3A43871551" target="_blank" >RIV/62157124:16370/12:43871551 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1107/S0021889812007546" target="_blank" >http://dx.doi.org/10.1107/S0021889812007546</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1107/S0021889812007546" target="_blank" >10.1107/S0021889812007546</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Application of constrained real-space refinement of flexible molecular fragments to automatic model building of RNA structures

Popis výsledku v původním jazyce

New methods have been developed for locating phosphate groups and nucleic acid bases in the electron density of RNA structures. These methods utilize a constrained real-space refinement of molecular fragments and a phased rotation-conformation-translation function. Real-space refinement has also contributed to the improvement of the bone/base method of RNA model building and to redesigning the method of building double helices in nucleic acid structures. This improvement is reflected in the increased accuracy of the model building and the ability to better distinguish between correct and false solutions. A program, RSR, was created, and the programs NUT, HEL and DHL were upgraded and organized into a program system, which is CCP4 oriented. Source codeswill also be released.

Název v anglickém jazyce

Application of constrained real-space refinement of flexible molecular fragments to automatic model building of RNA structures

Popis výsledku anglicky

New methods have been developed for locating phosphate groups and nucleic acid bases in the electron density of RNA structures. These methods utilize a constrained real-space refinement of molecular fragments and a phased rotation-conformation-translation function. Real-space refinement has also contributed to the improvement of the bone/base method of RNA model building and to redesigning the method of building double helices in nucleic acid structures. This improvement is reflected in the increased accuracy of the model building and the ability to better distinguish between correct and false solutions. A program, RSR, was created, and the programs NUT, HEL and DHL were upgraded and organized into a program system, which is CCP4 oriented. Source codeswill also be released.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Crystallography

ISSN

0021-8898

e-ISSN

—

Svazek periodika

45

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

309-315

Kód UT WoS článku

000302808300019

EID výsledku v databázi Scopus

—