Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872229" target="_blank" >RIV/62157124:16370/13:43872229 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/jps.23494" target="_blank" >http://dx.doi.org/10.1002/jps.23494</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jps.23494" target="_blank" >10.1002/jps.23494</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine

Popis výsledku v původním jazyce

Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transittimes for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca2+ ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. (C) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association

Název v anglickém jazyce

Designing a Dynamic Dissolution Method: A Review of Instrumental Options and Corresponding Physiology of Stomach and Small Intestine

Popis výsledku anglicky

Development of new pharmaceutical compounds and dosage forms often requires in vitro dissolution testing with the closest similarity to the human gastrointestinal (GI) tract. To create such conditions, one needs a suitable dissolution apparatus and the appropriate data on the human GI physiology. This review discusses technological approaches applicable in biorelevant dissolutions as well as the physiology of stomach and small intestine in both fasted and fed state, that is, volumes of contents, transittimes for water/food and various solid oral dosage forms, pH, osmolality, surface tension, buffer capacity, and concentrations of bile salts, phospholipids, enzymes, and Ca2+ ions. The information is aimed to provide clear suggestions on how these conditions should be set in a dynamic biorelevant dissolution test. (C) 2013 Wiley Periodicals, Inc. and the American Pharmacists Association

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmaceutical sciences

ISSN

0022-3549

e-ISSN

—

Svazek periodika

102

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

23

Strana od-do

2995-3017

Kód UT WoS článku

000330240900011

EID výsledku v databázi Scopus

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