In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872238" target="_blank" >RIV/62157124:16370/13:43872238 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2013/787283" target="_blank" >http://dx.doi.org/10.1155/2013/787283</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2013/787283" target="_blank" >10.1155/2013/787283</a>

Jazyk výsledku

angličtina

Název v původním jazyce

In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Popis výsledku v původním jazyce

This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide.

Název v anglickém jazyce

In Vitro Permeation of Micronized and Nanonized Alaptide from Semisolid Formulations

Popis výsledku anglicky

This study is focused on in vitro permeation of the original Czech compound, a skin/mucosa tissue regeneration promoter, known under the international nonproprietary name "alaptide," in micronized and nanonized forms. Alaptide showed a great potential for local applications for treatment and/or regeneration of the injured skin. The above mentioned technological modifications influence the permeation of alaptide through artificial or biological membranes, such as PAMPA or skin. The permeation of micronized and nanonized form of alaptide formulated to various semisolid pharmaceutical compositions through full-thickness pig ear skin using a Franz cell has been investigated in detail. In general, it can be concluded that the nanonized alaptide permeated through the skin less than the micronized form; different observations were made for permeation through the PAMPA system, where the micronized form showed lower permeation than the nanonized alaptide.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Cílený transport léčiva přes biologické membrány</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific World Journal

ISSN

1537-744X

e-ISSN

—

Svazek periodika

neuveden

Číslo periodika v rámci svazku

2013

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000329048400001

EID výsledku v databázi Scopus

—