Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873238" target="_blank" >RIV/62157124:16370/14:43873238 - isvavai.cz</a>

Výsledek na webu

<a href="http://pub.iapchem.org/ojs/index.php/admet/article/download/26/48" target="_blank" >http://pub.iapchem.org/ojs/index.php/admet/article/download/26/48</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5599/admet.2.1.26" target="_blank" >10.5599/admet.2.1.26</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Popis výsledku v původním jazyce

The investigation deals with the affection of permeation of mupirocin from the Bactroban(R) Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban(R) Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation.

Název v anglickém jazyce

Rapid Screening of Mupirocin Skin Permeation Modification by Micronized and Nanonized Alaptide

Popis výsledku anglicky

The investigation deals with the affection of permeation of mupirocin from the Bactroban(R) Leciva ointment through full-thickness pig ear skin by alaptide that was applied in micronized or nanonized form as a potential excipient. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, was the original Czech compound. It was discovered that micronized alaptide significantly enhanced the permeation of mupirocin within 1 h after administration (approx. 5-fold). On the other hand, nanonized alaptide almost completely inhibited permeation of mupirocin from Bactroban(R) Leciva through the skin. Rapid primary screening showed that the two forms of alaptide differently influenced the depth and the rate of permeation/penetration of mupirocin into/through the skin, i.e., affect curative effect of mupirocin on/in skin immediately after application of drug formulation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP304%2F11%2F2246" target="_blank" >GAP304/11/2246: Cílený transport léčiva přes biologické membrány</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ADMET & DMPK

ISSN

1848-7718

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

7

Strana od-do

56-62

Kód UT WoS článku

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EID výsledku v databázi Scopus

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