Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F13%3A43872326" target="_blank" >RIV/62157124:16370/13:43872326 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3797/scipharm.1208-19" target="_blank" >http://dx.doi.org/10.3797/scipharm.1208-19</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3797/scipharm.1208-19" target="_blank" >10.3797/scipharm.1208-19</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Popis výsledku v původním jazyce

The log BB parameter is the logarithm of the ratio of a compound's equilibrium concentrations in the brain tissue versus the blood plasma. This parameter is a useful descriptor in assessing the ability of a compound to permeate the blood-brain barrier. The aim of this study was to develop a Hansch-type linear regression QSAR model that correlates the parameter log BB and the retention time of drugs and other organic compounds on a reversed-phase HPLC containing an embedded amide moiety. The retention time was expressed by the capacity factor log k'. The second aim was to estimate the brain's absorption of 2-(azacycloalkyl)acetamidophenoxyacetic acids, which are analogues of piracetam, nefiracetam, and meclofenoxate. Notably, these acids may be novel nootropics. Two simple regression models that relate log BB and log k' were developed from an assay performed using a reversed-phase HPLC that contained an embedded amide moiety. Both the quadratic and linear models yielded statistical para

Název v anglickém jazyce

Chromatographic behaviour predicts the ability of potential nootropics to permeate the blood-brain barrier.

Popis výsledku anglicky

The log BB parameter is the logarithm of the ratio of a compound's equilibrium concentrations in the brain tissue versus the blood plasma. This parameter is a useful descriptor in assessing the ability of a compound to permeate the blood-brain barrier. The aim of this study was to develop a Hansch-type linear regression QSAR model that correlates the parameter log BB and the retention time of drugs and other organic compounds on a reversed-phase HPLC containing an embedded amide moiety. The retention time was expressed by the capacity factor log k'. The second aim was to estimate the brain's absorption of 2-(azacycloalkyl)acetamidophenoxyacetic acids, which are analogues of piracetam, nefiracetam, and meclofenoxate. Notably, these acids may be novel nootropics. Two simple regression models that relate log BB and log k' were developed from an assay performed using a reversed-phase HPLC that contained an embedded amide moiety. Both the quadratic and linear models yielded statistical para

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientia Pharmaceutica

ISSN

0036-8709

e-ISSN

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Svazek periodika

81

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

11

Strana od-do

81-91

Kód UT WoS článku

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EID výsledku v databázi Scopus

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