Antiurease activity of plants growing in the Czech Republic.
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43872672" target="_blank" >RIV/62157124:16370/14:43872672 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1080/14786419.2014.888553" target="_blank" >http://dx.doi.org/10.1080/14786419.2014.888553</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/14786419.2014.888553" target="_blank" >10.1080/14786419.2014.888553</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antiurease activity of plants growing in the Czech Republic.
Popis výsledku v původním jazyce
The antiurease activity of the aqueous extracts of 42 plants growing in the Czech Republic was investigated. A phenol-hypochlorite reaction was used for the determination of ammonia produced by urease. The inhibitory activity of the extracts at a concentration of 0.2 mg/mL varied from 17.8% to 80.0%. Extracts from six Potentilla species expressed inhibitory activity against jack bean urease. They were further investigated for their phenolic constituents and the major compounds were subjected to molecular docking. The results revealed that both jack bean urease and Helicobacter pylori urease were inhibited by quercetin-3-O-beta-D-galactopyranoside-6?-gallate (1), myricetin-3-O-beta-D-glucuronide (2), tiliroside (3) and B-type procyanidin (4). The antiurease activity of the investigated Potentilla species is probably due to the presence of complex phenolic constituents such as flavonoid glycosides and catechin dimers.
Název v anglickém jazyce
Antiurease activity of plants growing in the Czech Republic.
Popis výsledku anglicky
The antiurease activity of the aqueous extracts of 42 plants growing in the Czech Republic was investigated. A phenol-hypochlorite reaction was used for the determination of ammonia produced by urease. The inhibitory activity of the extracts at a concentration of 0.2 mg/mL varied from 17.8% to 80.0%. Extracts from six Potentilla species expressed inhibitory activity against jack bean urease. They were further investigated for their phenolic constituents and the major compounds were subjected to molecular docking. The results revealed that both jack bean urease and Helicobacter pylori urease were inhibited by quercetin-3-O-beta-D-galactopyranoside-6?-gallate (1), myricetin-3-O-beta-D-glucuronide (2), tiliroside (3) and B-type procyanidin (4). The antiurease activity of the investigated Potentilla species is probably due to the presence of complex phenolic constituents such as flavonoid glycosides and catechin dimers.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Natural product research
ISSN
1478-6419
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
12
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
868-873
Kód UT WoS článku
000335848500003
EID výsledku v databázi Scopus
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