IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873278" target="_blank" >RIV/62157124:16370/14:43873278 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT

Popis výsledku v původním jazyce

In order to find out if new perspective antagonists of beta-adrenergic receptors, ortho-/meta-alkoxyphenylcarbamic acid esters containing fluorinated N-phenylpiperazine fragment (labelled as 6a-6f and 8a-8e), might also act as the antioxidants, the aim of current study was to investigate their antioxidant profile by applying two in vitro methods. Following mentioned, the capability of these compounds to reduce relatively stable reference 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals in performed spectrophotometric analyses and to protect tyrosine from the peroxynitrite mediated nitration by applying the HPLC method was inspected. The position of alkoxy side chain bonded to lipophilic aromatic moiety as well as the ability of hydrogen bond formation and electrostatic effects, which have been induced by fluoro or trifluoromethyl substitution within the aromatic fragment of 4-phenylpiperazin-1-yl, have been considered the essential factors, which have influenced an antioxidant potential

Název v anglickém jazyce

IN VITRO ANTIOXIDANT PROPERTIES OF BASIC ortho-/meta-ALKOXYPHENYLCARBAMIC ACID ESTERS BEARING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL FRAGMENT

Popis výsledku anglicky

In order to find out if new perspective antagonists of beta-adrenergic receptors, ortho-/meta-alkoxyphenylcarbamic acid esters containing fluorinated N-phenylpiperazine fragment (labelled as 6a-6f and 8a-8e), might also act as the antioxidants, the aim of current study was to investigate their antioxidant profile by applying two in vitro methods. Following mentioned, the capability of these compounds to reduce relatively stable reference 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radicals in performed spectrophotometric analyses and to protect tyrosine from the peroxynitrite mediated nitration by applying the HPLC method was inspected. The position of alkoxy side chain bonded to lipophilic aromatic moiety as well as the ability of hydrogen bond formation and electrostatic effects, which have been induced by fluoro or trifluoromethyl substitution within the aromatic fragment of 4-phenylpiperazin-1-yl, have been considered the essential factors, which have influenced an antioxidant potential

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

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Svazek periodika

9A

Číslo periodika v rámci svazku

23

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

2361-2368

Kód UT WoS článku

000349805100019

EID výsledku v databázi Scopus

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