IN VITRO ANTIOXIDANT POTENTIAL OF para-ALKOXY-PHENYLCARBAMIC ACID ESTERS CONTAINING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL MOIETY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873514" target="_blank" >RIV/62157124:16370/15:43873514 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

IN VITRO ANTIOXIDANT POTENTIAL OF para-ALKOXY-PHENYLCARBAMIC ACID ESTERS CONTAINING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL MOIETY

Popis výsledku v původním jazyce

Antioxidant properties of certain beta-adrenoceptor blocking agents (beta-ABAs) may provide their significant benefit in the therapy of cardiovascular diseases. Considering mentioned, the potential of original beta-ABAs, para-alkoxy-phenylcarbamic acid esters 6i-6l and 8f-8i with incorporated 4-(4-fluoro- or 3-trifluoromethylphenyl)piperazin-1-yl fragment, to reduce stable 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot) applying UVNIS spectrophotometry and to scavenge peroxynitrite ions (ONOO-)using HPLC method, has been in vitro investigated. It has been observed that para-position of attached alkoxy group has appeared to be most suitable for antioxidative efficiency. The increase in lipophilicity in homological series 6i-6l and 8f-8i could be regarded as important but it has been questionable whether principal factor in terms of capabilities of these esters being effective reductants of DPPI-I. and the ONOO-scavengers as well. From entire evaluated set, para-methoxy substitu

Název v anglickém jazyce

IN VITRO ANTIOXIDANT POTENTIAL OF para-ALKOXY-PHENYLCARBAMIC ACID ESTERS CONTAINING 4-(4-FLUORO-/3-TRIFLUOROMETHYLPHENYL)PIPERAZIN-1-YL MOIETY

Popis výsledku anglicky

Antioxidant properties of certain beta-adrenoceptor blocking agents (beta-ABAs) may provide their significant benefit in the therapy of cardiovascular diseases. Considering mentioned, the potential of original beta-ABAs, para-alkoxy-phenylcarbamic acid esters 6i-6l and 8f-8i with incorporated 4-(4-fluoro- or 3-trifluoromethylphenyl)piperazin-1-yl fragment, to reduce stable 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot) applying UVNIS spectrophotometry and to scavenge peroxynitrite ions (ONOO-)using HPLC method, has been in vitro investigated. It has been observed that para-position of attached alkoxy group has appeared to be most suitable for antioxidative efficiency. The increase in lipophilicity in homological series 6i-6l and 8f-8i could be regarded as important but it has been questionable whether principal factor in terms of capabilities of these esters being effective reductants of DPPI-I. and the ONOO-scavengers as well. From entire evaluated set, para-methoxy substitu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

2310-2318

Kód UT WoS článku

000363071700006

EID výsledku v databázi Scopus

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