Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F14%3A43873352" target="_blank" >RIV/62157124:16370/14:43873352 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/179568" target="_blank" >http://dx.doi.org/10.1155/2014/179568</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/179568" target="_blank" >10.1155/2014/179568</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis

Popis výsledku v původním jazyce

Oralmucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, theirprotection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical filmcharacteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in

Název v anglickém jazyce

Evaluation of the influence of formulation and process variables on mechanical properties of oral mucoadhesive films using multivariate data analysis

Popis výsledku anglicky

Oralmucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, theirprotection against lesions, and their nonirritating properties. This work was focused on preparation of nonmedicated carmellose-based films using both solvent casting and impregnation methods, respectively. Moreover, a modern approach to evaluation of mucoadhesive films applying analysis of texture and subsequent multivariate data analysis was used. In this experiment, puncture strength strongly correlated with tensile strength and could be used to obtain necessary information about the mechanical filmcharacteristics in films prepared using both methods. Puncture work and tensile work were not correlated in films prepared using the solvent casting method, as increasing the amount of glycerol led to an increase in the puncture work in

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/NT14477" target="_blank" >NT14477: Moderní léková forma pro terapii orálních kandidóz</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomed Research International

ISSN

2314-6133

e-ISSN

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Svazek periodika

Neuveden

Číslo periodika v rámci svazku

2014

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

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Kód UT WoS článku

000340122800001

EID výsledku v databázi Scopus

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