Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43872703" target="_blank" >RIV/62157124:16370/15:43872703 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.2298/JSC131128032F" target="_blank" >http://dx.doi.org/10.2298/JSC131128032F</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2298/JSC131128032F" target="_blank" >10.2298/JSC131128032F</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
Popis výsledku v původním jazyce
Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was performed. The dobesilates were characterized by standard spectral methods and by AAS for metal content and then tested for inhibitory activity against aminopeptidase N. Calcium and magnesium 2,5-dihydroxybenzene sulfonates exhibited rather weak inhibitory activity to aminopeptidase N as demonstrated by IC50 values of 978.0 and 832.1 umol l-1 respectively while zinc 2,5-dihydroxybenzene sulfonate reached the more significant inhibitory activity characterized by IC5077.4 umol l-1. The inhibitory activity results suggest that the inhibition of aminopeptidase N could play a role in the anti-angiogenic activity of 2,5-dihydroxybenzenesulfonates.
Název v anglickém jazyce
Aminopeptidase N inhibition could be involved in the anti-angiogenic effect of dobesilates
Popis výsledku anglicky
Calcium, magnesium and zinc 2,5-dihydroxybenzenesulfonates (dobesilates) were synthesized by sulfonation of hydroquinone with sulfuric acid under mild conditions. To form the salts, neutralization with calcium carbonate followed by cation exchange by means of magnesium or zinc sulfates was performed. The dobesilates were characterized by standard spectral methods and by AAS for metal content and then tested for inhibitory activity against aminopeptidase N. Calcium and magnesium 2,5-dihydroxybenzene sulfonates exhibited rather weak inhibitory activity to aminopeptidase N as demonstrated by IC50 values of 978.0 and 832.1 umol l-1 respectively while zinc 2,5-dihydroxybenzene sulfonate reached the more significant inhibitory activity characterized by IC5077.4 umol l-1. The inhibitory activity results suggest that the inhibition of aminopeptidase N could play a role in the anti-angiogenic activity of 2,5-dihydroxybenzenesulfonates.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Serbian Chemical Society
ISSN
0352-5139
e-ISSN
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Svazek periodika
80
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
CS - Srbsko a Černá Hora
Počet stran výsledku
8
Strana od-do
605-612
Kód UT WoS článku
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EID výsledku v databázi Scopus
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