Development of Tablet Medical Form Containing Substance FS-1

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873523" target="_blank" >RIV/62157124:16370/15:43873523 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of Tablet Medical Form Containing Substance FS-1

Popis výsledku v původním jazyce

The original substance of the FS-1 is a nano-ion complex with bactericidal and virucidal activity which was developed in Scientific Center for Anti-infectious Drugs (Almaty, RK) and is intended for the treatment of tuberculosis. The purpose of presentedwork was to develop a rational and optimum technology for preparing of tablets based on the substance of FS-1, and to evaluate the effect of the time of hydrolysis on quality of the developed medical form. For this, 2 batches of FS-1 substance with timeof hydrolysis 17 min and 20 min were synthesized. The aim was to obtain tablets with suitable mechanical properties (friability below 1%) and a suitable disintegration time (up to 15 min), as is required by the Ph.Eur. Optimal formulation and process parameters for the preparation of tablets containing FS-1, under which tablets met the requirements for tablet disintegration time, tablet friability, and tablet mass and content uniformity, were identified within presented work. Longer time

Název v anglickém jazyce

Development of Tablet Medical Form Containing Substance FS-1

Popis výsledku anglicky

The original substance of the FS-1 is a nano-ion complex with bactericidal and virucidal activity which was developed in Scientific Center for Anti-infectious Drugs (Almaty, RK) and is intended for the treatment of tuberculosis. The purpose of presentedwork was to develop a rational and optimum technology for preparing of tablets based on the substance of FS-1, and to evaluate the effect of the time of hydrolysis on quality of the developed medical form. For this, 2 batches of FS-1 substance with timeof hydrolysis 17 min and 20 min were synthesized. The aim was to obtain tablets with suitable mechanical properties (friability below 1%) and a suitable disintegration time (up to 15 min), as is required by the Ph.Eur. Optimal formulation and process parameters for the preparation of tablets containing FS-1, under which tablets met the requirements for tablet disintegration time, tablet friability, and tablet mass and content uniformity, were identified within presented work. Longer time

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Research Journal of Pharmaceutical, Biological and Chemical Sciences

ISSN

0975-8585

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

1610-1615

Kód UT WoS článku

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EID výsledku v databázi Scopus

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