Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873547" target="_blank" >RIV/62157124:16370/15:43873547 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.3109/10837450.2014.926921" target="_blank" >http://dx.doi.org/10.3109/10837450.2014.926921</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10837450.2014.926921" target="_blank" >10.3109/10837450.2014.926921</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation
Popis výsledku v původním jazyce
Context: Liquisolid systems are modern formulations used to increase the bioavailability of poorly water-soluble drugs. Their preparation is based on the sorption of a drug in liquid state onto a carrier with a high adsorption capacity. The carrier particles are subsequently coated with material having a large surface area to form free-flowing powder. The main principle of bioavailability increasing is based on the presence of the dissolved drug, which is ready for immediate absorption in GI tract. Objective: Determination of capability of aluminometasilicate carrier Neusilin (R) US2 to adsorb different solvents. Materials and methods: The maximum amounts of polyethylene glycol 200 (PEG 200), polyethylene glycol 400 and propylene glycol (PG), which canbe sorbed by Neusilin (R) US2, while maintaining an acceptable flowability of the powder mixture, were evaluated using determination of the flowable liquid retention potential. Results and discussion: From the evaluation of liquisolid po
Název v anglickém jazyce
Determination of flowable liquid retention potential of aluminometasilicate carrier for liquisolid systems preparation
Popis výsledku anglicky
Context: Liquisolid systems are modern formulations used to increase the bioavailability of poorly water-soluble drugs. Their preparation is based on the sorption of a drug in liquid state onto a carrier with a high adsorption capacity. The carrier particles are subsequently coated with material having a large surface area to form free-flowing powder. The main principle of bioavailability increasing is based on the presence of the dissolved drug, which is ready for immediate absorption in GI tract. Objective: Determination of capability of aluminometasilicate carrier Neusilin (R) US2 to adsorb different solvents. Materials and methods: The maximum amounts of polyethylene glycol 200 (PEG 200), polyethylene glycol 400 and propylene glycol (PG), which canbe sorbed by Neusilin (R) US2, while maintaining an acceptable flowability of the powder mixture, were evaluated using determination of the flowable liquid retention potential. Results and discussion: From the evaluation of liquisolid po
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
ISSN
1083-7450
e-ISSN
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Svazek periodika
20
Číslo periodika v rámci svazku
7
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
839-844
Kód UT WoS článku
000361337500009
EID výsledku v databázi Scopus
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