EVALUATION OF SORPTIVE PROPERTIES OF VARIOUS CARRIERS AND COATING MATERIALS FOR LIQUISOLID SYSTEMS
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873549" target="_blank" >RIV/62157124:16370/15:43873549 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
EVALUATION OF SORPTIVE PROPERTIES OF VARIOUS CARRIERS AND COATING MATERIALS FOR LIQUISOLID SYSTEMS
Popis výsledku v původním jazyce
The basic principle of liquisolid systems formulation lies in the conversion of the drug in a liquid state into an apparently dry, free-flowing and readily compressible powder by its blending (or spraying) with specific carriers and coating materials. The selection of the most suitable carrier and coating material depends especially on their values of flowable liquid retention potential (Phi), which is defined as the maximum mass of liquid that can be retained per unit mass of powder material, while maintaining an acceptable flowability. The presented work focused on the determination of the maximum amount of propylene glycol (PG), which can be retained by several selected carriers and coating materials while maintaining acceptable flow properties of the liquisolid powder blend. Granulated forms of magnesium aluminometasilicates (Neusilin (R) US2 and Neusilin (R) NS2N), dibasic calcium phosphate (Fujicalin (R)) and microcrystalline cellulose (Avicel (R) PH 101) were tested due to their
Název v anglickém jazyce
EVALUATION OF SORPTIVE PROPERTIES OF VARIOUS CARRIERS AND COATING MATERIALS FOR LIQUISOLID SYSTEMS
Popis výsledku anglicky
The basic principle of liquisolid systems formulation lies in the conversion of the drug in a liquid state into an apparently dry, free-flowing and readily compressible powder by its blending (or spraying) with specific carriers and coating materials. The selection of the most suitable carrier and coating material depends especially on their values of flowable liquid retention potential (Phi), which is defined as the maximum mass of liquid that can be retained per unit mass of powder material, while maintaining an acceptable flowability. The presented work focused on the determination of the maximum amount of propylene glycol (PG), which can be retained by several selected carriers and coating materials while maintaining acceptable flow properties of the liquisolid powder blend. Granulated forms of magnesium aluminometasilicates (Neusilin (R) US2 and Neusilin (R) NS2N), dibasic calcium phosphate (Fujicalin (R)) and microcrystalline cellulose (Avicel (R) PH 101) were tested due to their
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Acta Poloniae Pharmaceutica - Drug Research
ISSN
0001-6837
e-ISSN
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Svazek periodika
72
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
PL - Polská republika
Počet stran výsledku
11
Strana od-do
539-549
Kód UT WoS článku
000363440000014
EID výsledku v databázi Scopus
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