Inhibition of Photosynthetic Electron Transport by 6-Hydroxynaphthalene-2-carboxanilides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F15%3A43873862" target="_blank" >RIV/62157124:16370/15:43873862 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Inhibition of Photosynthetic Electron Transport by 6-Hydroxynaphthalene-2-carboxanilides

Popis výsledku v původním jazyce

Inhibition of photosynthetic electron transport (PET) in spinach chloroplasts by 6-hydroxynaphthalene-2-carboxanilides has been investigated. The PET inhibiting activity of the studied compounds depends on compound lipophilicity, on the position of substituents on the anilide moiety as well as on electron-accepting and electron-donating properties of these substituents. The most active PET inhibitors are m-substituted derivatives; the lowest activity is shown by the o-substituted ones. The most potent PET inhibitor is 6-hydroxy-N-(3-trifluoromethylphenyl)naphthalene-2-carboxamide (IC50 = 10.8 ?mol/L). Study of chlorophyll a fluorescence in the suspension of spinach chloroplasts in the presence of studied compounds confirms their site of action in PS II, and it can be assumed that the inhibitory site of action of the studied compounds is situated on the acceptor side of PS II at QB site.

Název v anglickém jazyce

Inhibition of Photosynthetic Electron Transport by 6-Hydroxynaphthalene-2-carboxanilides

Popis výsledku anglicky

Inhibition of photosynthetic electron transport (PET) in spinach chloroplasts by 6-hydroxynaphthalene-2-carboxanilides has been investigated. The PET inhibiting activity of the studied compounds depends on compound lipophilicity, on the position of substituents on the anilide moiety as well as on electron-accepting and electron-donating properties of these substituents. The most active PET inhibitors are m-substituted derivatives; the lowest activity is shown by the o-substituted ones. The most potent PET inhibitor is 6-hydroxy-N-(3-trifluoromethylphenyl)naphthalene-2-carboxamide (IC50 = 10.8 ?mol/L). Study of chlorophyll a fluorescence in the suspension of spinach chloroplasts in the presence of studied compounds confirms their site of action in PS II, and it can be assumed that the inhibitory site of action of the studied compounds is situated on the acceptor side of PS II at QB site.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Indian journal of chemistry section B-organic chemistry including medicinal chemistry

ISSN

0376-4699

e-ISSN

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Svazek periodika

54B

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

IN - Indická republika

Počet stran výsledku

7

Strana od-do

1511-1517

Kód UT WoS článku

000367207500004

EID výsledku v databázi Scopus

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