INVESTIGATION OF ANTIOXIDANT POTENTIAL IN VITRO OF SOME SUBSTITUTED PHENYLCARBAMIC ACID DERIVATIVES CONTAINING 4 '-(PYRIMIDIN-2 '-YL)PIPERAZIN-1 '-YL AS SALT FORMING MOIETY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875576" target="_blank" >RIV/62157124:16370/17:43875576 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

INVESTIGATION OF ANTIOXIDANT POTENTIAL IN VITRO OF SOME SUBSTITUTED PHENYLCARBAMIC ACID DERIVATIVES CONTAINING 4 '-(PYRIMIDIN-2 '-YL)PIPERAZIN-1 '-YL AS SALT FORMING MOIETY

Popis výsledku v původním jazyce

Reactive oxygen and nitrogen species (ROS, RNS) have been normally produced in living biological systems in balance with biochemical antioxidants. Some of them have been found to be physiologically very useful, but they could also cause damage under certain circumstances. Excess production ROS and RNS, their generating in inappropriate relative amounts or deficiencies in antioxidant defenses might result in pathological stress to cells and tissues. Therapeutic effects of beta(1)-adrenoceptor antagonists (beta(1)-AdrAs) have been well-founded by their ability to block beta(1)-adrenergic receptors. In addition, some of beneficial cardiovascular effects shown by those class of the compounds have already been connected with the antioxidant properties that some of them have shown. Considering mentioned, the potential of prospective beta(1)-AdrAs, phenylcarbamic acid esters containing a 4&apos;-(pyrimidin-2--yl)piperazin-1&apos;-y1 fragment, to reduce a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot) applying the UV/VIS spectrophotometry and to scavenge peroxynitrite ions (ONOO-) by the HPLC method, has been investigated in vitro. Current research has revealed that those derivatives could be promising especially as the scavengers of the ONOO- ions. The paper has been focused on the alternatives in what kind of chemical pathways those compounds could play their health-beneficial roles. In addition, the investigation in silico of the molecules by employing calculated log P (CLOGP 4.0) and topological polar surface area (TPSA) outputs has predicted their favorable toxicological profile. Furthermore, when focusing on those compounds as non-antibiotic antimicrobials, a moderate capability to scavenge the ONOO- ions could be considered one of the reasons why the substances could not apparently been effective agents against some mycobacterial strains.

Název v anglickém jazyce

INVESTIGATION OF ANTIOXIDANT POTENTIAL IN VITRO OF SOME SUBSTITUTED PHENYLCARBAMIC ACID DERIVATIVES CONTAINING 4 '-(PYRIMIDIN-2 '-YL)PIPERAZIN-1 '-YL AS SALT FORMING MOIETY

Popis výsledku anglicky

Reactive oxygen and nitrogen species (ROS, RNS) have been normally produced in living biological systems in balance with biochemical antioxidants. Some of them have been found to be physiologically very useful, but they could also cause damage under certain circumstances. Excess production ROS and RNS, their generating in inappropriate relative amounts or deficiencies in antioxidant defenses might result in pathological stress to cells and tissues. Therapeutic effects of beta(1)-adrenoceptor antagonists (beta(1)-AdrAs) have been well-founded by their ability to block beta(1)-adrenergic receptors. In addition, some of beneficial cardiovascular effects shown by those class of the compounds have already been connected with the antioxidant properties that some of them have shown. Considering mentioned, the potential of prospective beta(1)-AdrAs, phenylcarbamic acid esters containing a 4&apos;-(pyrimidin-2--yl)piperazin-1&apos;-y1 fragment, to reduce a 2,2-diphenyl-1-picrylhydrazyl radical (DPPH center dot) applying the UV/VIS spectrophotometry and to scavenge peroxynitrite ions (ONOO-) by the HPLC method, has been investigated in vitro. Current research has revealed that those derivatives could be promising especially as the scavengers of the ONOO- ions. The paper has been focused on the alternatives in what kind of chemical pathways those compounds could play their health-beneficial roles. In addition, the investigation in silico of the molecules by employing calculated log P (CLOGP 4.0) and topological polar surface area (TPSA) outputs has predicted their favorable toxicological profile. Furthermore, when focusing on those compounds as non-antibiotic antimicrobials, a moderate capability to scavenge the ONOO- ions could be considered one of the reasons why the substances could not apparently been effective agents against some mycobacterial strains.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fresenius Environmental Bulletin

ISSN

1018-4619

e-ISSN

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Svazek periodika

26

Číslo periodika v rámci svazku

2A

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

1485-1494

Kód UT WoS článku

000396642600020

EID výsledku v databázi Scopus

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