Novel aspects on the direct compaction of ibuprofen with special focus on sticking

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43875578" target="_blank" >RIV/62157124:16370/17:43875578 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.powtec.2017.05.014" target="_blank" >http://dx.doi.org/10.1016/j.powtec.2017.05.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2017.05.014" target="_blank" >10.1016/j.powtec.2017.05.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel aspects on the direct compaction of ibuprofen with special focus on sticking

Popis výsledku v původním jazyce

Tableting of sticking active pharmaceutical ingredients (APIs) may cause time-consuming and costly complications. Therefore, the aim of this study was to identify and to analyze critical factors influencing sticking of ibuprofen during direct compaction with a laboratory tableting set-up and to find the optimum settings for sticking reduction using a design of experiments (DoE) approach. Moreover, the influence of the tablet punch wear on the sticking tendency was evaluated. In addition, the applicability of the small-scale experiments to production-scale tablet manufacture was investigated. The results of the DoE revealed that &quot;compaction force&quot;, &quot;punch tip coating&quot; and their interaction had the strongest impact on ibuprofen sticking to the punch tips. Furthermore, the wear of the punches had a pronounced influence on the anti-sticking properties of the different punch tip coatings. An additional minor influencing factor turned out to be the selection of the lubricant whereas the lubricants had a significant effect on the disintegration time of the tablets. This observation was in contrast to the expectations resulting from the lubricant hydrophobicity. The findings of the laboratory-scale tableting experiments were confirmed by the experiments conducted on the production scale.

Název v anglickém jazyce

Novel aspects on the direct compaction of ibuprofen with special focus on sticking

Popis výsledku anglicky

Tableting of sticking active pharmaceutical ingredients (APIs) may cause time-consuming and costly complications. Therefore, the aim of this study was to identify and to analyze critical factors influencing sticking of ibuprofen during direct compaction with a laboratory tableting set-up and to find the optimum settings for sticking reduction using a design of experiments (DoE) approach. Moreover, the influence of the tablet punch wear on the sticking tendency was evaluated. In addition, the applicability of the small-scale experiments to production-scale tablet manufacture was investigated. The results of the DoE revealed that &quot;compaction force&quot;, &quot;punch tip coating&quot; and their interaction had the strongest impact on ibuprofen sticking to the punch tips. Furthermore, the wear of the punches had a pronounced influence on the anti-sticking properties of the different punch tip coatings. An additional minor influencing factor turned out to be the selection of the lubricant whereas the lubricants had a significant effect on the disintegration time of the tablets. This observation was in contrast to the expectations resulting from the lubricant hydrophobicity. The findings of the laboratory-scale tableting experiments were confirmed by the experiments conducted on the production scale.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

317

Číslo periodika v rámci svazku

JUL 2017

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

370-380

Kód UT WoS článku

000404492600040

EID výsledku v databázi Scopus

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