Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10433673" target="_blank" >RIV/00216208:11160/21:10433673 - isvavai.cz</a>

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gpyf-V6PKm" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=gpyf-V6PKm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/star.202000166" target="_blank" >10.1002/star.202000166</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches

Popis výsledku v původním jazyce

Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized starches, namely, Starch 1500 and Lycatab C, from the perspectives of compressibility, compactability, and lubricant sensitivity. Compressibility is evaluated by means of the compression energy profile and a stress relaxation test. Compactability is evaluated by means of the tablets tensile strength, and lubricant sensitivity is characterized by the lubricant sensitivity ratio (LSR) values. The lubricants employed are magnesium stearate and sodium stearyl fumarate at concentrations of 0.5% and 1%, respectively. In the case of the mixtures with 1% magnesium stearate, the influence of the mixing time is also evaluated. Starch 1500 shows better compressibility than Lycatab C due to its lower precompression and total energy values. On the opposite, the plasticity is higher for Lycatab C. This material has also better compactability, yields stronger tablets, but has higher lubricant sensitivity than Starch 1500. Different compressibility and compactability are found for Lycatab C and Starch 1500 and therefore, they cannot be easily interchanged in tablet manufacture.

Název v anglickém jazyce

Comparison of Compressibility, Compactability, and Lubricant Sensitivity of Two Partially Pregelatinized Starches

Popis výsledku anglicky

Modified starches are widely employed excipients in tablets compression. The ability of materials to deform under pressure (compressibility) and create strong compacts (compactability) is then important for tablet manufacture. This study aims to evaluate and compare two partially pregelatinized starches, namely, Starch 1500 and Lycatab C, from the perspectives of compressibility, compactability, and lubricant sensitivity. Compressibility is evaluated by means of the compression energy profile and a stress relaxation test. Compactability is evaluated by means of the tablets tensile strength, and lubricant sensitivity is characterized by the lubricant sensitivity ratio (LSR) values. The lubricants employed are magnesium stearate and sodium stearyl fumarate at concentrations of 0.5% and 1%, respectively. In the case of the mixtures with 1% magnesium stearate, the influence of the mixing time is also evaluated. Starch 1500 shows better compressibility than Lycatab C due to its lower precompression and total energy values. On the opposite, the plasticity is higher for Lycatab C. This material has also better compactability, yields stronger tablets, but has higher lubricant sensitivity than Starch 1500. Different compressibility and compactability are found for Lycatab C and Starch 1500 and therefore, they cannot be easily interchanged in tablet manufacture.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Starch/Staerke

ISSN

0038-9056

e-ISSN

—

Svazek periodika

73

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

9

Strana od-do

2000166

Kód UT WoS článku

000596116900001

EID výsledku v databázi Scopus

2-s2.0-85097181744