Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62690094%3A18470%2F22%3A50018499" target="_blank" >RIV/62690094:18470/22:50018499 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/22:10450135

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0928098721003389" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0928098721003389</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejps.2021.106035" target="_blank" >10.1016/j.ejps.2021.106035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets

Popis výsledku v původním jazyce

Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck (R) ODT, Prosolv (R) ODT G2 and Ludiflash (R), and subsequently also the compactability and disintegration time of the tablets made thereof. The lubricants employed were magnesium stearate and sodium stearyl fumarate in the concentrations of 0.5% and 1%. The best flowability was shown by Prosolv (R) ODT G2 combined with magnesium stearate in the concentration of 0.5%. Lubricated mixtures with Prosolv (R) ODT G2 showed a lower angle of internal friction as well as lower pre-compression energy values. The values of plastic deformation energy were the highest in the case of Prosolv (R) ODT G2, which was also reflected in the highest tablet strength. On the contrary, the ejection force values were the lowest for this co-processed dry binder. Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv (R) ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time.

Název v anglickém jazyce

Study of rheological and tableting properties of lubricated mixtures of co-processed dry binders for orally disintegrating tablets

Popis výsledku anglicky

Co-processed dry binders for ODTs are important multifunctional excipients for tablet manufacturing by direct compression. Testing their binary mixtures with lubricants is an important aspect of their use in combination with drugs. The aim of this study was to evaluate the rheological and compression properties of lubricated mixtures of co-processed dry binders Parteck (R) ODT, Prosolv (R) ODT G2 and Ludiflash (R), and subsequently also the compactability and disintegration time of the tablets made thereof. The lubricants employed were magnesium stearate and sodium stearyl fumarate in the concentrations of 0.5% and 1%. The best flowability was shown by Prosolv (R) ODT G2 combined with magnesium stearate in the concentration of 0.5%. Lubricated mixtures with Prosolv (R) ODT G2 showed a lower angle of internal friction as well as lower pre-compression energy values. The values of plastic deformation energy were the highest in the case of Prosolv (R) ODT G2, which was also reflected in the highest tablet strength. On the contrary, the ejection force values were the lowest for this co-processed dry binder. Magnesium stearate reduced the ejection force more effectively than sodium stearyl fumarate. Prosolv (R) ODT G2 tablets exhibited the highest tensile strength and shortest disintegration time.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European journal of pharmaceutical sciences

ISSN

0928-0987

e-ISSN

1879-0720

Svazek periodika

168

Číslo periodika v rámci svazku

leden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

10

Strana od-do

"Article Number: 106035"

Kód UT WoS článku

000708663100006

EID výsledku v databázi Scopus

2-s2.0-85117198881