Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F17%3A43876008" target="_blank" >RIV/62157124:16370/17:43876008 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/17:00098635 RIV/00159816:_____/17:00067699

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.biopha.2017.03.099" target="_blank" >http://dx.doi.org/10.1016/j.biopha.2017.03.099</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.biopha.2017.03.099" target="_blank" >10.1016/j.biopha.2017.03.099</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Popis výsledku v původním jazyce

Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO(2)) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. Methods: The study was carried out on three groups of rats: control, MSG- and MSG + nCeO(2). They were injected with saline (control) or MSG. A month after born MSG- rats had been treated with water in a volume of 2.9 ml/kg, MSG + CeO2 groups - with CeO2 intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1 beta, IL-12Bp40, interferon-gamma (INF-gamma)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-beta (TGF-beta)) were measured by ELISA. Results: We have demonstrated the anti- obesity effect of nanocrystalline cerium dioxide and for the first time its anti- inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1 beta, IL-12Bp40) in rat serum and restored the level of anti- inflammatory cytokines (IL-4, IL-10, TGF-beta) to the control values. Conclusion: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti- oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury.

Název v anglickém jazyce

Cerium dioxide nanoparticles possess anti-inflammatory properties in the conditions of the obesity-associated NAFLD in rats

Popis výsledku anglicky

Background: Obesity is a risk factor for non-alcoholic fatty liver disease (NAFLD). The disease is associated with impairment of pro/antioxidant equilibrium and the inflammation in liver tissue. The aim of the work was to investigate the anti-inflammatory properties of the nanocrystalline cerium dioxide (nCeO(2)) on the rat model of NAFLD associated with monosodium glutamate (MSG)-induced obesity. Methods: The study was carried out on three groups of rats: control, MSG- and MSG + nCeO(2). They were injected with saline (control) or MSG. A month after born MSG- rats had been treated with water in a volume of 2.9 ml/kg, MSG + CeO2 groups - with CeO2 intragastrically (i.g.). The anthropometric and carbohydrate metabolism parameters, content of proinflammatory cytokines (interleukin (IL)-1 beta, IL-12Bp40, interferon-gamma (INF-gamma)) and anti-inflammatory cytokines (IL-4, IL-10, tumor growth factor-beta (TGF-beta)) were measured by ELISA. Results: We have demonstrated the anti- obesity effect of nanocrystalline cerium dioxide and for the first time its anti- inflammatory properties. Nanoparticles reduced the content of pro-inflammatory cytokines (IL-1 beta, IL-12Bp40) in rat serum and restored the level of anti- inflammatory cytokines (IL-4, IL-10, TGF-beta) to the control values. Conclusion: The precise mechanisms of this phenomenon remain to be unclear but we suppose they are at least partially associated with the strong anti- oxidant action of studied substance. Nanocrystalline cerium dioxide attenuates the inflammatory processes in rat blood that can prevent obesity complications and liver injury.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedicine &amp; pharmacotherapy

ISSN

0753-3322

e-ISSN

—

Svazek periodika

90

Číslo periodika v rámci svazku

JUN 2017

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

7

Strana od-do

608-614

Kód UT WoS článku

000402471000074

EID výsledku v databázi Scopus

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