Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876744" target="_blank" >RIV/62157124:16370/18:43876744 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081731:_____/18:00489601 RIV/00216224:14110/18:00102121 RIV/65269705:_____/18:00068541

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0361923017305828?token=FD89FE81B5199B092D887A4BD53C60D6CDDB35F512F1A12A80672CB1D32CCB1CEC54E0D8FC3937055BA77BB5A99BFA1F" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0361923017305828?token=FD89FE81B5199B092D887A4BD53C60D6CDDB35F512F1A12A80672CB1D32CCB1CEC54E0D8FC3937055BA77BB5A99BFA1F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.brainresbull.2017.11.008" target="_blank" >10.1016/j.brainresbull.2017.11.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment

Popis výsledku v původním jazyce

Background and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical anti psychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.

Název v anglickém jazyce

Poly(I:C) model of schizophrenia in rats induces sex-dependent functional brain changes detected by MRI that are not reversed by aripiprazole treatment

Popis výsledku anglicky

Background and purpose: One of the hallmarks of schizophrenia is altered brain structure, potentially due to antipsychotic treatment, the disorder itself or both. It was proposed that functional changes may precede the structural ones. In order to understand and potentially prevent this unwanted process, brain function assessment should be validated as a diagnostic tool. Methods: We used Arterial Spin Labelling MRI technique for the evaluation of brain perfusion in several brain regions in a neurodevelopmental poly(I:C) model of schizophrenia (8 mg/kg on a gestational day 15) in rats taking into account sex-dependent effects and chronic treatment with aripiprazole (30 days), an atypical anti psychotic acting as a partial agonist on dopaminergic receptors. Results: We found the sex of the animal to have a highly significant effect in all regions of interest, with females showing lower blood perfusion than males. However, both males and females treated prenatally with poly(I:C) showed enlargement of the lateral ventricles. Furthermore, we detected increased perfusion in the circle of Willis, hippocampus, and sensorimotor cortex, which was not influenced by chronic atypical antipsychotic aripiprazole treatment in male poly(I:C) rats. Conclusion: We hypothesize that perfusion alterations may be caused by the hyperdopaminergic activity in the poly(I:C) model, and the absence of aripiprazole effect on perfusion in brain regions related to schizophrenia may be due to its partial agonistic mechanism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Brain Research Bulletin

ISSN

0361-9230

e-ISSN

—

Svazek periodika

137

Číslo periodika v rámci svazku

March 2018

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

146-155

Kód UT WoS článku

000427344300016

EID výsledku v databázi Scopus

2-s2.0-85035792877