DIFFERENCE IN SYSTOLIC PRESSURE VALUES AT INFLATION AND DEFLATION OF THE CUFF IN RATS WITH GOLDBLATT RENAL HYPERTENSION

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43876876" target="_blank" >RIV/62157124:16370/18:43876876 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

DIFFERENCE IN SYSTOLIC PRESSURE VALUES AT INFLATION AND DEFLATION OF THE CUFF IN RATS WITH GOLDBLATT RENAL HYPERTENSION

Popis výsledku v původním jazyce

Clinically relevant animal models should mirror basic epidemiology data from real patients ? age, sex, primary disease i.e. diabetes, hypertension... Hypertension is most frequent concomitant disease and is the cause of many cardiovascular diseases. For our needs stroke study) we use Goldblatt renal hypertension model (GRHM). Three-month-old, male, Wistar rats were divided in groups: 2K1S (n=9), 2K2S (n=5), KON (n=11). In the 2K1S left renal artery was stenotized; in the 2K2S both renal arteries and in KON group a sham surgery was performed. Four months after surgery the blood pressure was measured (tail artery, rats cuff, vascular doppler flow detection). The measurement was performed under isoflurane anesthesia. The measurement was repeated 3 times and systolic arterial pressure values in cuff inflation (SAPi) and cuffs deflation (SAPd) were recorded. SAPi values (mean ? SD) were in 2K1S group 140?29 mm Hg, in 2K2S 144?20 mm Hg and in KON group 113?13mm Hg. Differences in systolic pressure at inflation and deflation of the cuff (SAPi-SAPd) were 12?4 mm Hg in 2K1S group, 11?5 mm Hg in 2K2S group and 2?2 mm Hg in KON group. GRHM produce elevation of SAPi-SAPd compared to control group.

Název v anglickém jazyce

DIFFERENCE IN SYSTOLIC PRESSURE VALUES AT INFLATION AND DEFLATION OF THE CUFF IN RATS WITH GOLDBLATT RENAL HYPERTENSION

Popis výsledku anglicky

Clinically relevant animal models should mirror basic epidemiology data from real patients ? age, sex, primary disease i.e. diabetes, hypertension... Hypertension is most frequent concomitant disease and is the cause of many cardiovascular diseases. For our needs stroke study) we use Goldblatt renal hypertension model (GRHM). Three-month-old, male, Wistar rats were divided in groups: 2K1S (n=9), 2K2S (n=5), KON (n=11). In the 2K1S left renal artery was stenotized; in the 2K2S both renal arteries and in KON group a sham surgery was performed. Four months after surgery the blood pressure was measured (tail artery, rats cuff, vascular doppler flow detection). The measurement was performed under isoflurane anesthesia. The measurement was repeated 3 times and systolic arterial pressure values in cuff inflation (SAPi) and cuffs deflation (SAPd) were recorded. SAPi values (mean ? SD) were in 2K1S group 140?29 mm Hg, in 2K2S 144?20 mm Hg and in KON group 113?13mm Hg. Differences in systolic pressure at inflation and deflation of the cuff (SAPi-SAPd) were 12?4 mm Hg in 2K1S group, 11?5 mm Hg in 2K2S group and 2?2 mm Hg in KON group. GRHM produce elevation of SAPi-SAPd compared to control group.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů