Determination of antitumor activity of biosynthesized silver nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F18%3A43877194" target="_blank" >RIV/62157124:16370/18:43877194 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of antitumor activity of biosynthesized silver nanoparticles

Popis výsledku v původním jazyce

Aim of this work was to monitor the effect of AgNPs prepared by green synthesis (AgNPsGS) on the MCF-7 breast tumor cell line and the H1299 lung tumor cell line and to compare this effect with AgNPs prepared by chemical synthesis (AgNPsCHS).The AgNPsGS were at a concentration of 160 ?M Ag+ ions cytotoxic for the both MCF-7 and HCT 116 tumor cell lines and reduced the metabolic activity of the cells to 0-20%. At a concentration of 80 ?M of Ag+ ions, cellular metabolic activity decreased to 0-60%. In contrast, AgNPsCHS were effective up to a much higher concentration of Ag+ ions (16 mM) and exhibited a lower inhibitory effect on both the MCF-7 and HCT 116 cell lines than the green synthesis nanoparticles.

Název v anglickém jazyce

Determination of antitumor activity of biosynthesized silver nanoparticles

Popis výsledku anglicky

Aim of this work was to monitor the effect of AgNPs prepared by green synthesis (AgNPsGS) on the MCF-7 breast tumor cell line and the H1299 lung tumor cell line and to compare this effect with AgNPs prepared by chemical synthesis (AgNPsCHS).The AgNPsGS were at a concentration of 160 ?M Ag+ ions cytotoxic for the both MCF-7 and HCT 116 tumor cell lines and reduced the metabolic activity of the cells to 0-20%. At a concentration of 80 ?M of Ag+ ions, cellular metabolic activity decreased to 0-60%. In contrast, AgNPsCHS were effective up to a much higher concentration of Ag+ ions (16 mM) and exhibited a lower inhibitory effect on both the MCF-7 and HCT 116 cell lines than the green synthesis nanoparticles.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů