Comprehensive study of co-processed excipients F- Melts (R): Flow, viscoelastic and compacts properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F19%3A43877718" target="_blank" >RIV/62157124:16370/19:43877718 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11160/19:10400134

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0032591019305406" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591019305406</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2019.07.048" target="_blank" >10.1016/j.powtec.2019.07.048</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comprehensive study of co-processed excipients F- Melts (R): Flow, viscoelastic and compacts properties

Popis výsledku v původním jazyce

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts (R) type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic properties and ejection force were assayed during the compression and the compacts were evaluated in compliance with the European Pharmacopoeia and subjected to other relevant testing (AFM imaging, wettability etc.). Based on the obtained results it could be stated that the C and M have very similar properties according to their similar composition. In general, it is difficult to select the best CPE as they possess different properties fitting the versatile needs of manufacturers. However, the obtained results revealed that the M and F1 are more suitable for the incorporation of moisture-sensitive ingredients than the C. (C) 2019 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Comprehensive study of co-processed excipients F- Melts (R): Flow, viscoelastic and compacts properties

Popis výsledku anglicky

This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts (R) type C, M and F1. All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were prepared using three compression pressures. The viscoelastic properties and ejection force were assayed during the compression and the compacts were evaluated in compliance with the European Pharmacopoeia and subjected to other relevant testing (AFM imaging, wettability etc.). Based on the obtained results it could be stated that the C and M have very similar properties according to their similar composition. In general, it is difficult to select the best CPE as they possess different properties fitting the versatile needs of manufacturers. However, the obtained results revealed that the M and F1 are more suitable for the incorporation of moisture-sensitive ingredients than the C. (C) 2019 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

355

Číslo periodika v rámci svazku

October

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

675-687

Kód UT WoS článku

000499760600068

EID výsledku v databázi Scopus

2-s2.0-85073643332