Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F21%3A10434425" target="_blank" >RIV/00216208:11160/21:10434425 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/21:73610447 RIV/00216224:14160/21:00122737

Výsledek na webu

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7qzMM5TeQt" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7qzMM5TeQt</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/pharmaceutics13091486" target="_blank" >10.3390/pharmaceutics13091486</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)

Popis výsledku v původním jazyce

The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs-Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)-were investigated using different methods, including granulometry, powder rheometry, and tablet compaction under three pressures. Due to the similar composition and the same preparation technique (spray drying), the properties of CPEs and their compacts were generally comparable. The most pronounced differences were observed in flowability, undissolved fraction after 3 min and 24 h, energy of plastic deformation (E-2), ejection force, consolidation behavior, and compact friability. Cellactose (R) 80 exhibited the most pronounced consolidation behavior, the lowest values of ejection force, and high friability of compacts. CombiLac (R) showed excellent flow properties but insufficient friability, except for compacts prepared at the highest compression pressure (182 MPa). MicroceLac (R) 100 displayed the poorest flow properties, lower ejection forces, and the best mechanical resistance of compacts. StarLac (R) showed excellent flow properties, the lowest amounts of undissolved fraction, the highest ejection force values, and the worst compact mechanical resistance. The obtained results revealed that higher compression pressures need to be used or further excipients have to be added to all tested materials in order to improve the friability and tensile strength of formed tablets, except for MicroceLac (R) 100.

Název v anglickém jazyce

Comparison of Flow and Compression Properties of Four Lactose-Based Co-Processed Excipients: Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)

Popis výsledku anglicky

The utilization of co-processed excipients (CPEs) represents a novel approach to the preparation of orally disintegrating tablets by direct compression. Flow, consolidation, and compression properties of four lactose-based CPEs-Cellactose (R) 80, CombiLac (R), MicroceLac (R) 100, and StarLac (R)-were investigated using different methods, including granulometry, powder rheometry, and tablet compaction under three pressures. Due to the similar composition and the same preparation technique (spray drying), the properties of CPEs and their compacts were generally comparable. The most pronounced differences were observed in flowability, undissolved fraction after 3 min and 24 h, energy of plastic deformation (E-2), ejection force, consolidation behavior, and compact friability. Cellactose (R) 80 exhibited the most pronounced consolidation behavior, the lowest values of ejection force, and high friability of compacts. CombiLac (R) showed excellent flow properties but insufficient friability, except for compacts prepared at the highest compression pressure (182 MPa). MicroceLac (R) 100 displayed the poorest flow properties, lower ejection forces, and the best mechanical resistance of compacts. StarLac (R) showed excellent flow properties, the lowest amounts of undissolved fraction, the highest ejection force values, and the worst compact mechanical resistance. The obtained results revealed that higher compression pressures need to be used or further excipients have to be added to all tested materials in order to improve the friability and tensile strength of formed tablets, except for MicroceLac (R) 100.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmaceutics

ISSN

1999-4923

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

21

Strana od-do

1486

Kód UT WoS článku

000701444400001

EID výsledku v databázi Scopus

2-s2.0-85116163555